3LMI

Crystal Structure of the Inactive Alpha-kinase Domain of Myosin Heavy Chain Kinase A (D766A) complex with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 5955

Chain	Residue
A	HOH301
A	LYS684
A	ARG734
A	SER735
A	THR736

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	HIS742
A	HIS794
A	CYS796
A	CYS800

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 1006

Chain	Residue
A	GLN758
A	ATP1760

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP A 1760

Chain	Residue
A	HOH64
A	HOH311
A	HOH473
A	ALA587
A	GLY589
A	ALA590
A	LEU591
A	ARG592
A	LYS645
A	GLU713
A	PRO714
A	LEU716
A	LYS722
A	ASP756
A	GLN758
A	ALA766
A	MG1006

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 5956

Chain	Residue
B	HOH246
B	LYS684
B	ARG734
B	SER735
B	THR736

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 5959

Chain	Residue
B	VAL581
B	GLU582
B	ARG583
B	TYR595
B	LEU646
B	ARG699

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1002

Chain	Residue
B	HIS742
B	HIS794
B	CYS796
B	CYS800

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 1005

Chain	Residue
B	GLN758
B	ATP1761

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP B 1761

Chain	Residue
B	HOH40
B	HOH156
B	HOH412
B	ALA587
B	GLY589
B	ALA590
B	LEU591
B	ARG592
B	LYS645
B	GLU713
B	PRO714
B	LEU716
B	LYS722
B	GLN758
B	ALA766
B	MG1005

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 5957

Chain	Residue
C	HOH281
C	LYS684
C	ARG734
C	SER735
C	THR736

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1003

Chain	Residue
C	HIS742
C	HIS794
C	CYS796
C	CYS800

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 1007

Chain	Residue
C	GLN758
C	ATP1762

---

site_id	BC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP C 1762

Chain	Residue
C	HOH167
C	HOH241
C	HOH277
C	HOH302
C	PHE586
C	ALA587
C	GLY589
C	ARG592
C	LYS645
C	GLU713
C	PRO714
C	LEU716
C	LYS722
C	ASP756
C	GLN758
C	ALA766
C	MG1007

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 5958

Chain	Residue
D	LYS684
D	ARG734
D	SER735
D	THR736

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 D 5960

Chain	Residue
D	HOH237
D	VAL581
D	GLU582
D	TYR595
D	ARG699

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1004

Chain	Residue
D	HIS794
D	CYS796
D	CYS800
D	HIS742

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 1008

Chain	Residue
D	GLN758
D	ATP1763

---

site_id	BC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP D 1763

Chain	Residue
D	HOH12
D	HOH112
D	HOH426
D	ALA587
D	GLY589
D	ALA590
D	ARG592
D	LYS645
D	GLU713
D	PRO714
D	LEU716
D	LYS722
D	ASP756
D	GLN758
D	ALA766
D	MG1008

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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