3LLR
Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006306 | biological_process | DNA methylation |
| A | 0009008 | molecular_function | DNA-methyltransferase activity |
| A | 0010468 | biological_process | regulation of gene expression |
| B | 0006306 | biological_process | DNA methylation |
| B | 0009008 | molecular_function | DNA-methyltransferase activity |
| B | 0010468 | biological_process | regulation of gene expression |
| C | 0006306 | biological_process | DNA methylation |
| C | 0009008 | molecular_function | DNA-methyltransferase activity |
| C | 0010468 | biological_process | regulation of gene expression |
| D | 0006306 | biological_process | DNA methylation |
| D | 0009008 | molecular_function | DNA-methyltransferase activity |
| D | 0010468 | biological_process | regulation of gene expression |
| E | 0006306 | biological_process | DNA methylation |
| E | 0009008 | molecular_function | DNA-methyltransferase activity |
| E | 0010468 | biological_process | regulation of gene expression |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BTB A 154 |
| Chain | Residue |
| A | PHE29 |
| A | TRP32 |
| A | TRP56 |
| A | ASP59 |
| A | LYS61 |
| A | MET90 |
| A | HOH184 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BTB B 154 |
| Chain | Residue |
| B | TRP32 |
| B | TRP56 |
| B | ASP59 |
| B | HOH171 |
| B | HOH214 |
| B | LEU26 |
| B | PHE29 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BTB C 154 |
| Chain | Residue |
| C | LEU26 |
| C | PHE29 |
| C | TRP32 |
| C | TRP56 |
| C | ASP59 |
| C | LYS61 |
| C | MET90 |
| C | HOH160 |
| C | HOH354 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BTB D 154 |
| Chain | Residue |
| D | LEU26 |
| D | PHE29 |
| D | TRP32 |
| D | TRP56 |
| D | ASP59 |
| D | MET90 |
| D | HOH339 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BTB E 154 |
| Chain | Residue |
| E | LEU26 |
| E | PHE29 |
| E | TRP32 |
| E | TRP56 |
| E | ASP59 |
| E | MET90 |
| E | HOH166 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 155 |
| Chain | Residue |
| B | LEU26 |
| B | ARG27 |
| B | HOH216 |
| B | HOH362 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 290 |
| Details | Domain: {"description":"PWWP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00162","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
