3L9E

Crystal structures of holo and Cu-deficient Cu/ZnSOD from the silkworm Bombyx mori and the implications in Amyotrophic lateral sclerosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005737	cellular_component	cytoplasm
A	0006801	biological_process	superoxide metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004784	molecular_function	superoxide dismutase activity
B	0005507	molecular_function	copper ion binding
B	0005737	cellular_component	cytoplasm
B	0006801	biological_process	superoxide metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004784	molecular_function	superoxide dismutase activity
C	0005507	molecular_function	copper ion binding
C	0005737	cellular_component	cytoplasm
C	0006801	biological_process	superoxide metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004784	molecular_function	superoxide dismutase activity
D	0005507	molecular_function	copper ion binding
D	0005737	cellular_component	cytoplasm
D	0006801	biological_process	superoxide metabolic process
D	0008270	molecular_function	zinc ion binding
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 155

Chain	Residue
A	HIS62
A	HIS70
A	HIS79
A	ASP82

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 155

Chain	Residue
B	HIS62
B	HIS70
B	HIS79
B	ASP82

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 155

Chain	Residue
C	HIS70
C	HIS79
C	ASP82
C	HIS62

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 155

Chain	Residue
D	HIS62
D	HIS70
D	HIS79
D	ASP82

---

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
A	GLY43-THR53

---

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGgRiACgvI

Chain	Residue	Details
A	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:20310068, ECO:0007744|PDB:3L9Y

Chain	Residue	Details
A	HIS45
D	HIS45
D	HIS47
D	HIS120
A	HIS47
A	HIS120
B	HIS45
B	HIS47
B	HIS120
C	HIS45
C	HIS47
C	HIS120

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:20310068, ECO:0007744|PDB:3L9E, ECO:0007744|PDB:3L9Y

Chain	Residue	Details
A	HIS62
C	HIS70
C	HIS79
C	ASP82
D	HIS62
D	HIS70
D	HIS79
D	ASP82
A	HIS70
A	HIS79
A	ASP82
B	HIS62
B	HIS70
B	HIS79
B	ASP82
C	HIS62

---