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3L8J

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001525biological_processangiogenesis
A0003158biological_processendothelium development
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0008284biological_processpositive regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030335biological_processpositive regulation of cell migration
A0032874biological_processpositive regulation of stress-activated MAPK cascade
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035023biological_processregulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036481biological_processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043149biological_processstress fiber assembly
A0043406biological_processpositive regulation of MAP kinase activity
A0044319biological_processwound healing, spreading of cells
A0045747biological_processpositive regulation of Notch signaling pathway
A0045765biological_processregulation of angiogenesis
A0050821biological_processprotein stabilization
A0051683biological_processestablishment of Golgi localization
A0070062cellular_componentextracellular exosome
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090168biological_processGolgi reassembly
A0090316biological_processpositive regulation of intracellular protein transport
A0090443cellular_componentFAR/SIN/STRIPAK complex
A1903358biological_processregulation of Golgi organization
A1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS179

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS186

218853

PDB entries from 2024-04-24

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