3L85

Crystal structure of human NUDT5 complexed with 8-oxo-dGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
B	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 8OG A 1

Chain	Residue
A	TRP46
A	GLU47
A	HOH303
B	TRP28
B	ARG51
B	ARG84
B	ALA96
B	GLY97

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 8OG A 2

Chain	Residue
B	THR45
B	TRP46
B	GLU47
A	TRP28

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GliddgEtpeaAAlRELeEEtG

Chain	Residue	Details
A	GLY97-GLY118

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: in other chain => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126

Chain	Residue	Details
A	TRP28
A	ARG84
B	TRP28
B	ARG84

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126

Chain	Residue	Details
A	TRP46
B	GLU112
B	GLU116
B	GLU166
A	ARG51
A	ALA96
A	GLU112
A	GLU116
A	GLU166
B	TRP46
B	ARG51
B	ALA96

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: in other chain => ECO:0000269|PubMed:17052728

Chain	Residue	Details
A	LEU98
A	ASP133
B	LEU98
B	ASP133

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:27257257

Chain	Residue	Details
A	THR45
B	THR45

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
A	TYR74
B	TYR74

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS42
B	LYS42

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