3L7U

Crystal structure of human NM23-H1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0004520	molecular_function	DNA endonuclease activity
A	0004536	molecular_function	DNA nuclease activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004673	molecular_function	protein histidine kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005769	cellular_component	early endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006284	biological_process	base-excision repair
A	0006308	biological_process	DNA catabolic process
A	0006309	biological_process	apoptotic DNA fragmentation
A	0006720	biological_process	isoprenoid metabolic process
A	0006753	biological_process	nucleoside phosphate metabolic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008626	biological_process	granzyme-mediated apoptotic signaling pathway
A	0009132	biological_process	nucleoside diphosphate metabolic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
A	0019003	molecular_function	GDP binding
A	0032587	cellular_component	ruffle membrane
A	0034214	biological_process	protein hexamerization
A	0042304	biological_process	regulation of fatty acid biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043024	molecular_function	ribosomal small subunit binding
A	0043531	molecular_function	ADP binding
A	0046042	biological_process	ITP biosynthetic process
A	0046356	biological_process	acetyl-CoA catabolic process
A	0047887	molecular_function	farnesyl diphosphate kinase activity
A	0050679	biological_process	positive regulation of epithelial cell proliferation
A	0070062	cellular_component	extracellular exosome
A	0072521	biological_process	purine-containing compound metabolic process
A	0106310	molecular_function	protein serine kinase activity
A	0120225	molecular_function	coenzyme A binding
A	0120226	molecular_function	succinyl-CoA binding
A	1905502	molecular_function	acetyl-CoA binding
B	0000287	molecular_function	magnesium ion binding
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0004520	molecular_function	DNA endonuclease activity
B	0004536	molecular_function	DNA nuclease activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0004673	molecular_function	protein histidine kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005769	cellular_component	early endosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006284	biological_process	base-excision repair
B	0006308	biological_process	DNA catabolic process
B	0006309	biological_process	apoptotic DNA fragmentation
B	0006720	biological_process	isoprenoid metabolic process
B	0006753	biological_process	nucleoside phosphate metabolic process
B	0008285	biological_process	negative regulation of cell population proliferation
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008626	biological_process	granzyme-mediated apoptotic signaling pathway
B	0009132	biological_process	nucleoside diphosphate metabolic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
B	0019003	molecular_function	GDP binding
B	0032587	cellular_component	ruffle membrane
B	0034214	biological_process	protein hexamerization
B	0042304	biological_process	regulation of fatty acid biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043024	molecular_function	ribosomal small subunit binding
B	0043531	molecular_function	ADP binding
B	0046042	biological_process	ITP biosynthetic process
B	0046356	biological_process	acetyl-CoA catabolic process
B	0047887	molecular_function	farnesyl diphosphate kinase activity
B	0050679	biological_process	positive regulation of epithelial cell proliferation
B	0070062	cellular_component	extracellular exosome
B	0072521	biological_process	purine-containing compound metabolic process
B	0106310	molecular_function	protein serine kinase activity
B	0120225	molecular_function	coenzyme A binding
B	0120226	molecular_function	succinyl-CoA binding
B	1905502	molecular_function	acetyl-CoA binding
C	0000287	molecular_function	magnesium ion binding
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0004520	molecular_function	DNA endonuclease activity
C	0004536	molecular_function	DNA nuclease activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0004673	molecular_function	protein histidine kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005769	cellular_component	early endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006284	biological_process	base-excision repair
C	0006308	biological_process	DNA catabolic process
C	0006309	biological_process	apoptotic DNA fragmentation
C	0006720	biological_process	isoprenoid metabolic process
C	0006753	biological_process	nucleoside phosphate metabolic process
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008296	molecular_function	3'-5'-DNA exonuclease activity
C	0008626	biological_process	granzyme-mediated apoptotic signaling pathway
C	0009132	biological_process	nucleoside diphosphate metabolic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
C	0019003	molecular_function	GDP binding
C	0032587	cellular_component	ruffle membrane
C	0034214	biological_process	protein hexamerization
C	0042304	biological_process	regulation of fatty acid biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043024	molecular_function	ribosomal small subunit binding
C	0043531	molecular_function	ADP binding
C	0046042	biological_process	ITP biosynthetic process
C	0046356	biological_process	acetyl-CoA catabolic process
C	0047887	molecular_function	farnesyl diphosphate kinase activity
C	0050679	biological_process	positive regulation of epithelial cell proliferation
C	0070062	cellular_component	extracellular exosome
C	0072521	biological_process	purine-containing compound metabolic process
C	0106310	molecular_function	protein serine kinase activity
C	0120225	molecular_function	coenzyme A binding
C	0120226	molecular_function	succinyl-CoA binding
C	1905502	molecular_function	acetyl-CoA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 153

Chain	Residue
B	ARG88
B	THR94
B	HIS118
B	HOH328
B	HOH366

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 B 154

Chain	Residue
B	HOH245
B	HOH374
C	GLN17
C	ARG18
C	HOH196
C	HOH290
C	HOH345
A	CYS145
A	ALA146
B	ARG18
B	HOH174

---

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSV

Chain	Residue	Details
A	ASN115-VAL123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"1851158","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8810265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8529641","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15532","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P52175","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12972261","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1UCN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"2HVE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"25582197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"S-glutathionyl cysteine; alternate","evidences":[{"source":"PubMed","id":"19956735","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25582197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---