Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TAR A 2 |
| Chain | Residue |
| A | ARG68 |
| A | ASN89 |
| A | HIS110 |
| A | ARG111 |
| A | ASN175 |
| A | HOH553 |
| A | HOH612 |
| A | HOH627 |
| A | HOH789 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BDW A 1 |
| Chain | Residue |
| A | ASP93 |
| A | GLY95 |
| A | TYR132 |
| A | ILE171 |
| A | ILE187 |
| A | ARG189 |
| A | ASP289 |
| A | GLY291 |
| A | THR292 |
| A | THR293 |
| A | HOH844 |
| A | HOH855 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TAR B 1 |
| Chain | Residue |
| A | LYS300 |
| B | HIS106 |
| B | PHE108 |
| B | SER166 |
| B | ASP167 |
| B | LYS168 |
| B | PHE169 |
| B | PHE170 |
| B | HOH484 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TAR B 3 |
| Chain | Residue |
| B | ARG68 |
| B | ASN89 |
| B | HIS110 |
| B | ARG111 |
| B | ASN175 |
| B | HOH522 |
| B | HOH586 |
| B | HOH671 |
| B | HOH676 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE BDW B 455 |
| Chain | Residue |
| B | GLN73 |
| B | LEU91 |
| B | ASP93 |
| B | GLY95 |
| B | SER96 |
| B | VAL130 |
| B | ILE187 |
| B | ARG189 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | HOH813 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 341 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
