3L4K
Topoisomerase II-DNA cleavage complex, metal-bound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | HIS735 |
| A | GLU808 |
| A | ASP809 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 3 |
| Chain | Residue |
| A | ZN4 |
| A | GLU449 |
| A | ASP526 |
| A | PTR782 |
| B | DC11 |
| D | TSP11 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 4 |
| Chain | Residue |
| A | ZN3 |
| A | ASP526 |
| A | ASP528 |
| A | LYS603 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN A 5 |
| Chain | Residue |
| A | HIS981 |
| A | GLU1175 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 6 |
| Chain | Residue |
| A | GLU615 |
| A | HIS623 |
| A | ASP859 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 7 |
| Chain | Residue |
| A | GLN553 |
| A | HIS628 |
| A | GLU669 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN A 8 |
| Chain | Residue |
| A | HIS736 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TSP D 11 |
| Chain | Residue |
| A | ZN3 |
| A | GLU449 |
| A | LYS477 |
| A | ASP530 |
| A | HIS736 |
| A | GLY737 |
| A | PTR782 |
| C | DC1 |
| C | DG5 |
| C | DT6 |
| D | DT10 |
| E | DC1 |
| E | DA5 |
| E | DA6 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN E 16 |
| Chain | Residue |
| C | DG4 |
| E | DG4 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSALS |
| Chain | Residue | Details |
| A | LEU447-SER455 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 114 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20485342","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01384","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20485342","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9685374","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18097402","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20485342","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"20485342","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for DNA bending; intercalates between base pairs of target DNA","evidences":[{"source":"PubMed","id":"18097402","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
