3L4K

Topoisomerase II-DNA cleavage complex, metal-bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HIS735
A	GLU808
A	ASP809

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	ZN4
A	GLU449
A	ASP526
A	PTR782
B	DC11
D	TSP11

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	ZN3
A	ASP526
A	ASP528
A	LYS603

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 5

Chain	Residue
A	HIS981
A	GLU1175

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 6

Chain	Residue
A	GLU615
A	HIS623
A	ASP859

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 7

Chain	Residue
A	GLN553
A	HIS628
A	GLU669

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN A 8

Chain	Residue
A	HIS736

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TSP D 11

Chain	Residue
A	ZN3
A	GLU449
A	LYS477
A	ASP530
A	HIS736
A	GLY737
A	PTR782
C	DC1
C	DG5
C	DT6
D	DT10
E	DC1
E	DA5
E	DA6

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 16

Chain	Residue
C	DG4
E	DG4

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSALS

Chain	Residue	Details
A	LEU447-SER455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:20485342, ECO:0000269|PubMed:9685374

Chain	Residue	Details
A	PTR782

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:18097402

Chain	Residue	Details
A	GLU449
A	ASP526
A	ASP528

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995

Chain	Residue	Details
A	LYS477
A	TYR734
A	SER740
A	TRP908

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:20485342

Chain	Residue	Details
A	ASN480
A	ARG650
A	LYS651
A	LYS700

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:20485342

Chain	Residue	Details
A	ARG781

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Important for DNA bending; intercalates between base pairs of target DNA => ECO:0000269|PubMed:18097402

Chain	Residue	Details
A	ILE833

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:1316274

Chain	Residue	Details
A	THR1086

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:1316274

Chain	Residue	Details
A	SER1087

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