3L2P

Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003909	molecular_function	DNA ligase activity
A	0003910	molecular_function	DNA ligase (ATP) activity
A	0005524	molecular_function	ATP binding
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP A 901

Chain	Residue
A	GLU419
A	LYS590
C	DG12
A	ILE420
A	LYS421
A	TYR422
A	ARG426
A	PHE508
A	LYS573
A	TRP586
A	LYS588

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Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	23
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGLVLKdvkgt...YEpgk...Rhwl..KVK

Chain	Residue	Details
A	GLU568-LYS590

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site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EIKYDGERV

Chain	Residue	Details
A	GLU419-VAL427

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: N6-AMP-lysine intermediate => ECO:0000255|PROSITE-ProRule:PRU10135, ECO:0000269|PubMed:20518483

Chain	Residue	Details
A	LYS421

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305, ECO:0007744|PDB:3L2P

Chain	Residue	Details
A	GLU419
A	ARG426
A	LYS573

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG441
A	GLU473
A	GLU568
A	ARG584
A	LYS588

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