3L28
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | TYR229 |
| A | PHE235 |
| A | GLY236 |
| A | HIS240 |
| A | GLN244 |
| A | HOH345 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 8 |
| Chain | Residue |
| A | ARG283 |
| B | ARG322 |
| B | HOH421 |
| A | SER266 |
| A | ASP271 |
| A | GLN279 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 10 |
| Chain | Residue |
| A | HOH46 |
| A | SER220 |
| A | ALA221 |
| A | LYS222 |
| A | LYS251 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | GLN274 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 9 |
| Chain | Residue |
| A | ASP257 |
| A | HIS260 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 12 |
| Chain | Residue |
| A | ASP230 |
| B | ARG312 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1 |
| Chain | Residue |
| B | NA4 |
| B | LEU232 |
| B | PRO233 |
| B | GLY234 |
| B | PHE235 |
| B | GLY236 |
| B | THR237 |
| B | HIS240 |
| B | HOH342 |
| B | HOH365 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2 |
| Chain | Residue |
| B | HOH14 |
| B | HOH115 |
| B | LYS319 |
| B | ARG322 |
| B | HOH451 |
| E | PRO293 |
| E | VAL294 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | NA3 |
| B | ALA221 |
| B | ARG225 |
| B | LYS251 |
| B | HOH345 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 3 |
| Chain | Residue |
| B | SO45 |
| B | LYS222 |
| B | CL341 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 4 |
| Chain | Residue |
| A | HOH17 |
| B | SO41 |
| B | THR237 |
| B | GLN274 |
| B | HOH365 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 341 |
| Chain | Residue |
| B | NA3 |
| B | ALA221 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 8 |
| Chain | Residue |
| B | SER266 |
| B | ASP271 |
| B | GLN279 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 2 |
| Chain | Residue |
| C | HOH59 |
| C | PRO318 |
| C | LYS319 |
| C | TRP324 |
| D | GLY270 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL C 11 |
| Chain | Residue |
| C | ARG322 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 4 |
| Chain | Residue |
| D | NA1 |
| D | HOH58 |
| D | LEU232 |
| D | PRO233 |
| D | GLY234 |
| D | PHE235 |
| D | GLY236 |
| D | THR237 |
| D | HIS240 |
| D | HOH352 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 9 |
| Chain | Residue |
| D | HOH90 |
| D | ARG225 |
| D | HOH452 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 1 |
| Chain | Residue |
| A | ASP332 |
| D | SO44 |
| D | HOH18 |
| D | LEU232 |
| D | HIS240 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 341 |
| Chain | Residue |
| D | SER317 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 7 |
| Chain | Residue |
| D | ARG322 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 3 |
| Chain | Residue |
| E | HOH89 |
| E | SER266 |
| E | GLU269 |
| E | ASP271 |
| E | GLN279 |
| E | HOH444 |
| F | ARG322 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA E 5 |
| Chain | Residue |
| E | GLU269 |
| F | SO47 |
| F | HOH20 |
| F | HOH25 |
| F | SER317 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 341 |
| Chain | Residue |
| E | GLN279 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 F 7 |
| Chain | Residue |
| F | LYS319 |
| F | ARG322 |
| F | HOH357 |
| E | NA5 |
| E | HOH8 |
| F | HOH135 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 6 |
| Chain | Residue |
| E | HOH443 |
| F | GLU269 |
| F | ARG283 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 10 |
| Chain | Residue |
| F | GLU262 |
| F | ARG283 |
| F | PRO285 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31694758","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28679761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35533195","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
