3L27
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 5 |
| Chain | Residue |
| A | GLY236 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 7 |
| Chain | Residue |
| A | THR281 |
| A | LYS282 |
| A | VAL284 |
| A | GLN288 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1 |
| Chain | Residue |
| A | GOL341 |
| C | HOH98 |
| C | ILE258 |
| C | PRO285 |
| A | HOH127 |
| A | ARG322 |
| A | TRP324 |
| A | LYS339 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 3 |
| Chain | Residue |
| A | GLN288 |
| A | ASP289 |
| A | LYS319 |
| A | ASP321 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 9 |
| Chain | Residue |
| A | ARG283 |
| B | GOL7 |
| B | ARG322 |
| B | GOL341 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 341 |
| Chain | Residue |
| A | PO41 |
| A | HOH189 |
| A | LYS282 |
| A | ASP321 |
| A | ARG322 |
| C | ARG283 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 4 |
| Chain | Residue |
| A | ILE227 |
| A | HIS231 |
| A | GLN264 |
| A | LEU267 |
| A | HOH345 |
| B | LYS309 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 8 |
| Chain | Residue |
| A | SER220 |
| A | ALA221 |
| A | LYS222 |
| A | LYS251 |
| A | HOH351 |
| A | HOH359 |
| A | HOH363 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 3 |
| Chain | Residue |
| B | HOH114 |
| B | PRO285 |
| B | ILE286 |
| B | GLN288 |
| C | HOH177 |
| C | ILE286 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 4 |
| Chain | Residue |
| B | PRO217 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 6 |
| Chain | Residue |
| B | GOL1 |
| B | SER220 |
| B | ALA221 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 8 |
| Chain | Residue |
| B | GOL341 |
| C | HOH371 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 9 |
| Chain | Residue |
| B | HOH344 |
| D | HOH151 |
| D | PHE235 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 2 |
| Chain | Residue |
| B | HOH132 |
| B | ILE227 |
| B | HIS231 |
| B | GLN264 |
| B | HOH350 |
| B | HOH352 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1 |
| Chain | Residue |
| B | CL6 |
| B | SER220 |
| B | LYS222 |
| B | ARG225 |
| B | LYS251 |
| B | HOH357 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 7 |
| Chain | Residue |
| A | PO49 |
| A | ARG283 |
| B | LYS282 |
| B | ASP321 |
| B | GLY323 |
| B | ILE340 |
| B | HOH356 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 341 |
| Chain | Residue |
| A | PO49 |
| A | HOH96 |
| B | CL8 |
| B | HOH104 |
| B | PRO315 |
| B | ARG322 |
| B | TRP324 |
| B | LYS339 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 2 |
| Chain | Residue |
| A | LEU232 |
| A | GLY234 |
| A | HOH342 |
| A | HOH343 |
| C | LEU232 |
| C | GLY234 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 C 7 |
| Chain | Residue |
| C | GLN288 |
| C | ASP289 |
| C | LYS319 |
| C | ASP321 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 341 |
| Chain | Residue |
| C | ALA221 |
| C | LYS222 |
| C | ARG225 |
| C | LYS251 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 10 |
| Chain | Residue |
| C | VAL294 |
| C | HIS296 |
| C | HOH368 |
| C | HOH371 |
| B | ARG322 |
| B | HOH367 |
| C | PRO293 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 1 |
| Chain | Residue |
| B | LEU232 |
| B | GLY234 |
| B | HOH344 |
| D | HOH2 |
| D | LEU232 |
| D | GLY234 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 4 |
| Chain | Residue |
| D | HOH123 |
| D | ILE227 |
| D | HIS231 |
| D | GLN264 |
| D | HOH355 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 5 |
| Chain | Residue |
| D | GLN288 |
| D | ASP289 |
| D | LYS319 |
| D | ASP321 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 D 6 |
| Chain | Residue |
| B | HOH71 |
| B | HOH370 |
| D | HOH94 |
| D | ARG322 |
| D | TRP324 |
| D | LYS339 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 8 |
| Chain | Residue |
| C | TRP324 |
| C | LYS339 |
| C | HOH343 |
| D | HOH68 |
| D | GOL342 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 341 |
| Chain | Residue |
| D | HOH179 |
| D | SER220 |
| D | ALA221 |
| D | LYS222 |
| D | ARG225 |
| D | LYS251 |
| D | HOH361 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 342 |
| Chain | Residue |
| C | LYS282 |
| C | ASP321 |
| C | ARG322 |
| D | PO48 |
| D | ARG283 |
| D | HOH371 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31694758","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28679761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35533195","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
