3L25

Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1

Chain	Residue
A	FMT11
A	FMT12
A	GLY236
A	PRO304

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 2

Chain	Residue
A	ARG300

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 10

Chain	Residue
A	PHE235
A	HOH353
A	HOH32
A	HOH185
A	LEU232
A	GLY234

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 341

Chain	Residue
A	ARG305
A	HOH343
E	TRP324
F	U5
F	G6
F	HOH10

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 3

Chain	Residue
A	PHE235
A	ARG305
B	GLN329
E	PRO316

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 11

Chain	Residue
A	MG1
A	TYR229
A	HIS240
A	GLN244

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 12

Chain	Residue
A	MG1
A	PHE235
A	GLY236
A	HIS240
B	ASP332

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 16

Chain	Residue
A	HOH28
A	PRO293
A	VAL294
E	FMT8
E	ARG305

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 19

Chain	Residue
A	HOH33
A	GLN274
A	HOH363
C	G6
C	HOH89

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 5

Chain	Residue
B	GLN264

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 6

Chain	Residue
B	HOH71
B	LEU232
B	PRO233
B	GLY234
B	PHE235

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 13

Chain	Residue
B	HOH29
B	PRO315
B	PRO316
E	PRO315
E	PRO316

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 10

Chain	Residue
B	GLY301
B	ASP302

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT B 341

Chain	Residue
B	HOH140
B	SER317
B	PRO318
B	LYS319
B	ARG322
B	TRP324

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT B 17

Chain	Residue
B	HOH204
B	ALA265
B	GLU269
B	HOH357

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT B 18

Chain	Residue
B	FMT22
B	GLY236
B	THR237
B	GLN241
B	GLN244
B	PRO304
B	CYS307

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT B 22

Chain	Residue
B	FMT18
B	PHE235
B	GLY236
B	HIS240
D	HOH358

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 23

Chain	Residue
B	LYS282
B	ASP321

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT B 25

Chain	Residue
B	LYS282
B	VAL284
B	GLN288

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 9

Chain	Residue
A	HOH33
C	U5
C	HOH89
D	HOH34
F	U5
F	HOH54

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 10

Chain	Residue
C	U5
C	G6
C	HOH37
C	HOH40
C	HOH285
F	HOH121

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 12

Chain	Residue
C	C3
C	HOH307
D	HOH151
D	SER310
D	HOH344
D	HOH362

---

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FMT C 11

Chain	Residue
C	A4
C	HOH27
C	HOH50
C	HOH77
C	HOH108
D	THR237
D	PHE239
F	G6
C	C3

---

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT C 24

Chain	Residue
A	HOH145
A	PHE239
C	G6
C	HOH36
C	HOH107
C	HOH124
F	C3
F	A4

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 4

Chain	Residue
D	HIS231

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 8

Chain	Residue
D	HOH10
D	HOH59
D	LEU232
D	GLY234
D	PHE235
D	HOH343

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT D 2

Chain	Residue
D	HOH86
D	ASN254
D	SER255
D	LEU256
D	ASP257
D	ILE258

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT D 341

Chain	Residue
C	U5
C	HOH14
D	ARG305
D	HOH364
D	HOH370

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT D 6

Chain	Residue
B	PRO316
D	PHE235
D	ARG305
E	GLN329
E	HOH350

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT D 20

Chain	Residue
D	HOH34
D	GLN274
D	HOH357
F	G6
F	HOH54

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT D 21

Chain	Residue
B	ARG305
D	HOH199
D	LEU249
D	PRO293
D	HOH360

---

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 3

Chain	Residue
E	SER299
E	ARG300

---

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT E 7

Chain	Residue
E	GLN241

---

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT E 8

Chain	Residue
A	FMT16
A	HOH74
A	VAL294
E	HOH44
E	ARG305
E	ALA306

---

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT E 14

Chain	Residue
D	PHE235
D	GLY236
D	HIS240
E	ASP332
E	GLY333
E	HOH351
E	HOH369

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT E 15

Chain	Residue
A	HOH112
A	ASP332

---

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 11

Chain	Residue
C	HOH217
F	U5
F	G6
F	HOH16
F	HOH58
F	HOH297

---

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT F 9

Chain	Residue
A	HOH178
F	G2
F	C3
F	HOH142
F	HOH175
F	HOH316

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31694758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28679761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35533195","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---