3KX2

Crystal structure of Prp43p in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000390	biological_process	spliceosomal complex disassembly
A	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005739	cellular_component	mitochondrion
A	0006364	biological_process	rRNA processing
A	0006397	biological_process	mRNA processing
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0022613	biological_process	ribonucleoprotein complex biogenesis
A	0030490	biological_process	maturation of SSU-rRNA
A	0030686	cellular_component	90S preribosome
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0071014	cellular_component	post-mRNA release spliceosomal complex
B	0000166	molecular_function	nucleotide binding
B	0000390	biological_process	spliceosomal complex disassembly
B	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003729	molecular_function	mRNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005739	cellular_component	mitochondrion
B	0006364	biological_process	rRNA processing
B	0006397	biological_process	mRNA processing
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0022613	biological_process	ribonucleoprotein complex biogenesis
B	0030490	biological_process	maturation of SSU-rRNA
B	0030686	cellular_component	90S preribosome
B	0042273	biological_process	ribosomal large subunit biogenesis
B	0071014	cellular_component	post-mRNA release spliceosomal complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 800

Chain	Residue
B	THR123
B	SER382
B	HOH901
B	HOH902
B	HOH903
B	HOH904
B	ADP1000

---

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ADP B 1000

Chain	Residue
B	THR118
B	GLY119
B	SER120
B	GLY121
B	LYS122
B	THR123
B	THR124
B	ARG159
B	PHE357
B	THR384
B	ASP386
B	ARG430
B	MG800
B	HOH811
B	HOH836
B	HOH901
B	HOH902
B	HOH903
B	HOH985
B	HOH1162
B	HOH1167
B	LEU93
B	GLU117

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 800

Chain	Residue
A	THR123
A	HOH901
A	HOH902
A	HOH903
A	HOH904
A	ADP1000

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 1000

Chain	Residue
A	LEU93
A	GLU117
A	THR118
A	GLY119
A	SER120
A	GLY121
A	LYS122
A	THR123
A	THR124
A	ARG159
A	PHE357
A	THR384
A	ASP386
A	ARG430
A	MG800
A	HOH901
A	HOH902
A	HOH903
A	HOH933
A	HOH1012
A	HOH1063
A	HOH1141

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIILDEAHE

Chain	Residue	Details
B	SER210-GLU219

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	330
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	360
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	146
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---