3KVO
Crystal structure of the catalytic domain of human Hydroxysteroid dehydrogenase like 2 (HSDL2)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP A 501 |
| Chain | Residue |
| A | GLY17 |
| A | ASP74 |
| A | VAL75 |
| A | ASN101 |
| A | ALA102 |
| A | SER103 |
| A | VAL124 |
| A | ILE151 |
| A | TYR168 |
| A | LYS172 |
| A | TRP196 |
| A | SER19 |
| A | ALA200 |
| A | ILE201 |
| A | THR203 |
| A | ALA205 |
| A | MET206 |
| A | ASP271 |
| A | HOH317 |
| A | HOH318 |
| A | HOH324 |
| A | NAP502 |
| A | ARG20 |
| A | GLY21 |
| A | ILE22 |
| A | ALA41 |
| A | LYS42 |
| A | THR43 |
| A | VAL73 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NAP A 502 |
| Chain | Residue |
| A | LYS42 |
| A | ARG76 |
| A | LYS116 |
| A | ARG117 |
| A | LEU120 |
| A | HOH322 |
| A | NAP501 |
| B | LYS163 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP B 501 |
| Chain | Residue |
| B | GLY17 |
| B | SER19 |
| B | ARG20 |
| B | GLY21 |
| B | ILE22 |
| B | ALA41 |
| B | LYS42 |
| B | THR43 |
| B | VAL73 |
| B | ASP74 |
| B | VAL75 |
| B | ASN101 |
| B | ALA102 |
| B | SER103 |
| B | VAL124 |
| B | ILE151 |
| B | LYS172 |
| B | TRP196 |
| B | PRO197 |
| B | ALA200 |
| B | ILE201 |
| B | THR203 |
| B | ALA205 |
| B | ASP271 |
| B | HOH316 |
| B | HOH319 |
| B | HOH332 |
| B | NAP502 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NAP B 502 |
| Chain | Residue |
| B | LYS42 |
| B | ARG76 |
| B | ARG117 |
| B | LEU120 |
| B | NAP501 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. LnlnpvwfkqHcaYTIAKYGMsMYVlGMA |
| Chain | Residue | Details |
| A | LEU155-ALA183 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (HSDL2).","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"29192674","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q2TPA8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
