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3KVO

Crystal structure of the catalytic domain of human Hydroxysteroid dehydrogenase like 2 (HSDL2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0016491molecular_functionoxidoreductase activity
B0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAP A 501
ChainResidue
AGLY17
AASP74
AVAL75
AASN101
AALA102
ASER103
AVAL124
AILE151
ATYR168
ALYS172
ATRP196
ASER19
AALA200
AILE201
ATHR203
AALA205
AMET206
AASP271
AHOH317
AHOH318
AHOH324
ANAP502
AARG20
AGLY21
AILE22
AALA41
ALYS42
ATHR43
AVAL73

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NAP A 502
ChainResidue
ALYS42
AARG76
ALYS116
AARG117
ALEU120
AHOH322
ANAP501
BLYS163

site_idAC3
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAP B 501
ChainResidue
BGLY17
BSER19
BARG20
BGLY21
BILE22
BALA41
BLYS42
BTHR43
BVAL73
BASP74
BVAL75
BASN101
BALA102
BSER103
BVAL124
BILE151
BLYS172
BTRP196
BPRO197
BALA200
BILE201
BTHR203
BALA205
BASP271
BHOH316
BHOH319
BHOH332
BNAP502

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NAP B 502
ChainResidue
BLYS42
BARG76
BARG117
BLEU120
BNAP501

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. LnlnpvwfkqHcaYTIAKYGMsMYVlGMA
ChainResidueDetails
ALEU155-ALA183

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
ChainResidueDetails
ATYR168
BTYR168

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|Ref.12
ChainResidueDetails
AGLY17
ALYS42
AASP74
ALYS172
BGLY17
BLYS42
BASP74
BLYS172

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
ChainResidueDetails
ALYS42
BLYS42

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q2TPA8
ChainResidueDetails
ALYS116
BLYS116

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PDB entries from 2024-11-13

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