3KV4

Structure of PHF8 in complex with histone H3

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 448

Chain	Residue
A	CYS8
A	CYS10
A	HIS31
A	CYS34
A	EDO452

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 449

Chain	Residue
A	CYS23
A	CYS26
A	CYS50
A	CYS53

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 450

Chain	Residue
A	HIS247
A	ASP249
A	HIS319
A	HOH553
A	OGA5798

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 451

Chain	Residue
A	SER214
A	TRP215
A	VAL216
A	PHE334
A	LEU335

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EDO A 452

Chain	Residue
A	CYS10
A	LEU12
A	ARG18
A	HIS31
A	CYS34
A	LEU104
A	PHE115
A	GLU118
A	ASN119
A	ZN448
A	HOH472

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 453

Chain	Residue
A	ARG92
A	ASN202
A	ILE265
A	LYS302

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 454

Chain	Residue
A	PHE96
A	SER98
A	ARG199
A	HOH500
A	HOH512
A	HOH608

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 455

Chain	Residue
A	ARG270
A	HOH514

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 456

Chain	Residue
A	ARG18
A	SER33
A	GLU118

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 457

Chain	Residue
A	LYS212
A	LEU213
A	SER214
A	TRP215
A	EDO459

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 458

Chain	Residue
A	ARG89
A	ASP131
A	GLY132
A	GLY134

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 459

Chain	Residue
A	SER337
A	HIS374
A	ILE378
A	EDO457

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 460

Chain	Residue
A	ASP44
A	ILE45
A	SER60
A	ILE61
A	MET62

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 461

Chain	Residue
A	VAL35
A	VAL37
A	TYR48
A	HIS49
A	PRO51
A	GLU54

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 462

Chain	Residue
A	ASN52
A	VAL55
A	SER98
A	ASP100
A	GLU101

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 463

Chain	Residue
A	THR355

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 464

Chain	Residue
A	ASP161
A	CYS168
A	MET170
A	LYS186

---

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE OGA A 5798

Chain	Residue
A	ASN189
A	THR244
A	HIS247
A	ASP249
A	TYR257
A	LYS264
A	HIS319
A	VAL321
A	FE2450
A	HOH479
A	HOH553
B	MLY9

---

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
B	LYS14-LEU20

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. ClCrlPYdvtrfmieC

Chain	Residue	Details
A	CYS8-CYS23

---

site_id	PS01359
Number of Residues	46
Details	ZF_PHD_1 Zinc finger PHD-type signature. Cl.Crlpydvtrfm...................................IeCdm..Cqdw.FHgsCvgveeekaadidl................................YhCpnC

Chain	Residue	Details
A	CYS8-CYS53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
B	ARG2
B	ARG17

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	THR3
A	LYS264

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	M3L4
B	LYS18
B	LYS23

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	THR6
B	THR11

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
B	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
B	MLY9

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000250|UniProtKB:P68432

Chain	Residue	Details
B	SER10

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
B	LYS14

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