Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3KQX

Structure of a protease 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0019538	biological_process	protein metabolic process
G	0030145	molecular_function	manganese ion binding
G	0046872	molecular_function	metal ion binding
G	0070006	molecular_function	metalloaminopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0019538	biological_process	protein metabolic process
H	0030145	molecular_function	manganese ion binding
H	0046872	molecular_function	metal ion binding
H	0070006	molecular_function	metalloaminopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0019538	biological_process	protein metabolic process
I	0030145	molecular_function	manganese ion binding
I	0046872	molecular_function	metal ion binding
I	0070006	molecular_function	metalloaminopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0019538	biological_process	protein metabolic process
J	0030145	molecular_function	manganese ion binding
J	0046872	molecular_function	metal ion binding
J	0070006	molecular_function	metalloaminopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0019538	biological_process	protein metabolic process
K	0030145	molecular_function	manganese ion binding
K	0046872	molecular_function	metal ion binding
K	0070006	molecular_function	metalloaminopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0019538	biological_process	protein metabolic process
L	0030145	molecular_function	manganese ion binding
L	0046872	molecular_function	metal ion binding
L	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	LYS374
A	ASP379
A	ASP399
A	GLU461
A	HOH4267
A	HOH4274

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 A 1002

Chain	Residue
A	GLY462
A	ARG463
A	LEU487
A	HOH4267
A	LYS374
A	ALA460
A	GLU461

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ILE101
A	GLU102
A	TYR103
A	ASN104

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	GLU125
A	GLY126
A	LEU219
A	SER220
A	HOH4029
G	LYS111

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 19

Chain	Residue
A	TYR103
A	ASN104
A	TYR411
A	HOH1912

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE A 20

Chain	Residue
A	TYR103
A	GLU316
A	LYS320

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE A 24

Chain	Residue
A	MET392
A	GLY489
A	HOH4274

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 57

Chain	Residue
A	ASN449
A	LYS451
A	ASP543
A	HOH3368
B	SER254

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 1001

Chain	Residue
B	LYS374
B	ASP379
B	ASP399
B	GLU461
B	HOH4281

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 B 1002

Chain	Residue
B	LYS374
B	ALA460
B	GLU461
B	GLY462
B	ARG463
B	LEU487

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 3

Chain	Residue
A	SER435
A	LYS436
B	SER435
B	LYS436
C	SER435
C	LYS436

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 12

Chain	Residue
B	GLU125
B	GLY126
B	LEU219
B	SER220

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2PE B 13

Chain	Residue
B	2PE14
B	TYR103
B	ASN104
H	2PE6
H	TYR103
H	ASN104
H	HIS108
H	GLU282
H	HOH3089
H	HOH3267

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2PE B 14

Chain	Residue
B	2PE13
B	TYR103
B	HIS108
B	LYS320
B	TYR411
H	2PE6
H	TYR103
H	GLU316
H	GLN319
H	LYS320

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE B 40

Chain	Residue
B	GLY390
B	MET392
B	MET396
B	PHE398
B	GLY489
B	HOH4281

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 1001

Chain	Residue
C	LYS374
C	ASP379
C	ASP399
C	GLU461
C	HOH4276

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 C 1002

Chain	Residue
C	LYS374
C	ASP459
C	ALA460
C	GLU461
C	GLY462
C	ARG463
C	LEU487

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 6

Chain	Residue
C	ASN531
C	GLU532
C	HOH1209
C	HOH4105
D	TYR499
C	ILE529
C	ILE530

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 15

Chain	Residue
C	GLY126
C	LEU219
C	SER220

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 16

Chain	Residue
C	ASN505
C	ASN506
C	ALA570
C	HOH3395
C	HOH3904

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE C 17

Chain	Residue
C	TYR103
C	GLU316
C	LYS320

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE C 18

Chain	Residue
C	TYR103
C	ASN104
C	HIS108
C	TYR411
C	HOH997

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE C 41

Chain	Residue
C	GLY390
C	MET392
C	ALA577
C	HOH2344
C	HOH4276

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 1001

Chain	Residue
D	LYS374
D	ASP379
D	ASP399
D	GLU461
D	HOH4275

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 D 1002

Chain	Residue
D	LYS374
D	ALA460
D	GLU461
D	GLY462
D	ARG463
D	LEU487

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 5

Chain	Residue
D	ILE101
D	GLU102
D	TYR103
D	ASN104

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 7

Chain	Residue
D	SER435
D	LYS436
E	SER435
E	LYS436
F	SER435
F	LYS436

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 10

Chain	Residue
D	ASN545
D	SER549
D	HOH650
D	HOH2932
D	HOH3188
D	HOH3694
E	ARG586

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE D 9

Chain	Residue
D	TYR103
D	ASN104
D	HIS108
D	PHE289
D	TYR411
D	HOH1759

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE D 612

Chain	Residue
D	HIS108
D	ILE110
D	GLU282
D	ARG285
L	HIS108
L	ILE110
L	LYS111

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE D 23

Chain	Residue
D	GLY390
D	MET392
D	LEU487
D	GLY489
D	ALA577
D	HOH4275

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE D 34

Chain	Residue
D	TYR499
D	SER517
D	LYS518
D	VAL524

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE D 44

Chain	Residue
D	ASN449
D	LYS451
D	ARG534
D	ASP543
D	GLU564
D	GLN567
E	SER254

site_id	DC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE D 62

Chain	Residue
A	PHE156
A	ASN161
D	TYR176
D	MET177
D	PHE178
D	SER184
D	VAL185
D	HOH4357

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN E 1001

Chain	Residue
E	LYS374
E	ASP379
E	ASP399
E	GLU461
E	HOH4271
E	HOH4272

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 E 1002

Chain	Residue
E	LYS374
E	ALA460
E	GLY462
E	ARG463
E	LEU487
E	HOH4272

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 11

Chain	Residue
E	ASN505
E	ASN506
E	THR569
E	ALA570

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE E 7

Chain	Residue
E	GLN319
E	LYS320

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE E 8

Chain	Residue
E	TYR103
E	HIS108
E	PHE289
E	LYS320
E	TYR411
E	HOH4239

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE E 28

Chain	Residue
E	MET392
E	PHE398
E	THR486
E	GLY489
E	HOH2510
E	HOH4271

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE E 35

Chain	Residue
E	SER517
E	LYS518
E	VAL524
E	TRP525

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE E 43

Chain	Residue
E	LYS451
E	ARG534
E	ASP543
E	GLU564
F	SER254
F	HOH1799

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE E 46

Chain	Residue
E	LEU214
E	ASN217
E	GLU250
E	GLU262
E	TYR263

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1001

Chain	Residue
F	LYS374
F	ASP379
F	ASP399
F	GLU461

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 F 1002

Chain	Residue
F	LYS374
F	ALA460
F	GLU461
F	GLY462
F	ARG463
F	LEU487

site_id	FC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE F 31

Chain	Residue
F	TYR103
F	ASN104
F	HIS108
F	LYS320
F	TYR411

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE F 32

Chain	Residue
F	TYR103
F	GLU316
F	LYS320

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE F 33

Chain	Residue
D	SER254
F	ASN449
F	LYS451
F	ASP543
F	GLN567
F	HOH2592
F	HOH3563

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE F 53

Chain	Residue
F	VAL524
F	HOH4301

site_id	FC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 2PE F 63

Chain	Residue
F	MET392
F	GLY489

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN G 1001

Chain	Residue
G	LYS374
G	ASP379
G	ASP399
G	GLU461
G	HOH4256
G	HOH4257

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 G 1002

Chain	Residue
G	LYS374
G	ALA460
G	GLY462
G	ARG463
G	LEU487
G	HOH4257

site_id	FC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 G 23

Chain	Residue
G	ARG586
G	HOH1824
G	HOH1897
G	HOH2767
I	ASN545
I	SER549
I	HOH1784

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE G 12

Chain	Residue
G	1PE58
G	TYR103
G	ASN104
G	HIS108
G	TYR411

site_id	GC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE G 16

Chain	Residue
G	MET392
G	PHE398
G	THR486
G	GLY489
G	LEU492
G	HOH3348
G	HOH4256

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE G 30

Chain	Residue
G	TRP526
G	HOH649
G	HOH656
G	HOH3290
L	TRP525

site_id	GC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1PE G 47

Chain	Residue
A	TYR115
A	ASN122
A	GLU124
A	TYR270
G	1PE48
G	TYR115
G	ASN122
G	GLU124
G	TYR270

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE G 48

Chain	Residue
A	ASN122
G	1PE47
G	ASN122

site_id	GC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE G 58

Chain	Residue
G	1PE12
G	TYR103
G	ASN104
G	GLU316
G	GLN319
G	LYS320

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 1001

Chain	Residue
H	LYS374
H	ASP379
H	ASP399
H	GLU461
H	HOH4259

site_id	GC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 H 1002

Chain	Residue
H	LYS374
H	ALA460
H	GLU461
H	GLY462
H	ARG463
H	LEU487

site_id	GC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 2PE H 6

Chain	Residue
B	2PE13
B	2PE14
B	TYR103
B	GLU316
B	LYS320
B	HOH3232
H	TYR103
H	LYS320
H	LEU321

site_id	GC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE H 51

Chain	Residue
H	MET392
H	THR486
H	GLY489
H	HOH4259
H	HOH4290

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE H 54

Chain	Residue
G	GLU454
G	GLY456
H	ASP394
H	LEU395
H	HOH1879
H	HOH4310

site_id	HC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN I 1001

Chain	Residue
I	LYS374
I	ASP379
I	ASP399
I	GLU461
I	HOH4260
I	HOH4261

site_id	HC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 I 1002

Chain	Residue
I	LYS374
I	ALA460
I	GLU461
I	GLY462
I	ARG463
I	LEU487
I	HOH4261

site_id	HC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 I 17

Chain	Residue
G	SER435
G	LYS436
H	SER435
H	LYS436
I	SER435
I	LYS436

site_id	HC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE I 21

Chain	Residue
I	1PE22
I	TYR103
I	GLU316
I	LYS320

site_id	HC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE I 22

Chain	Residue
I	1PE21
I	TYR103
I	ASN104
I	HIS108
I	TYR411
I	HOH962

site_id	HC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE I 27

Chain	Residue
I	GLY390
I	MET392
I	PHE398
I	GLY489
I	ALA577
I	HOH4260

site_id	HC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE I 61

Chain	Residue
I	ILE529
I	ILE530
I	ASN531
I	GLU532
I	HOH1183
J	TYR499
J	HOH3537
J	HOH4349

site_id	HC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN J 1001

Chain	Residue
J	1PE15
J	LYS374
J	ASP379
J	ASP399
J	GLU461
J	CO31002

site_id	IC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO3 J 1002

Chain	Residue
J	LYS374
J	ALA460
J	GLY462
J	ARG463
J	LEU487
J	ZN1001

site_id	IC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 J 20

Chain	Residue
J	ASN545
J	SER549
J	HOH663
J	HOH4241
J	HOH4278
K	ARG586
K	HOH2810

site_id	IC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE J 2

Chain	Residue
J	TYR103
J	HIS108
J	PHE289
J	LYS320
J	LEU321
J	TYR411
J	HOH785

site_id	IC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE J 3

Chain	Residue
J	GLU316
J	LYS320
J	HOH3661

site_id	IC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE J 15

Chain	Residue
J	GLY390
J	MET392
J	ASP399
J	THR486
J	GLY489
J	LEU492
J	ZN1001

site_id	IC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE J 45

Chain	Residue
J	ASN449
J	LYS451
J	ARG534
J	ASP543
J	GLU564
J	GLN567
K	SER254

site_id	IC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE J 49

Chain	Residue
F	HIS108
F	ASP109
F	LYS111
F	ARG285
J	HIS108
J	ILE110
J	LYS111
J	GLU282
J	ARG285
J	HOH3642

site_id	IC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE J 60

Chain	Residue
J	SER517
J	LYS518
J	VAL524

site_id	IC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 1001

Chain	Residue
K	LYS374
K	ASP379
K	ASP399
K	GLU461
K	HOH4264

site_id	JC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO3 K 1002

Chain	Residue
K	LYS374
K	ALA460
K	GLY462
K	ARG463
K	LEU487

site_id	JC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 K 18

Chain	Residue
J	SER435
J	LYS436
K	SER435
K	LYS436
L	SER435
L	LYS436

site_id	JC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 K 19

Chain	Residue
K	1PE4
K	ILE101
K	GLU102
K	TYR103
K	ASN104
K	HOH1969

site_id	JC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE K 36

Chain	Residue
K	MET392
K	THR486
K	LEU487
K	GLY489
K	HOH4264

site_id	JC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE K 4

Chain	Residue
K	SO419
K	GLU316
K	LYS320

site_id	JC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE K 5

Chain	Residue
K	TYR103
K	HIS108
K	PHE289
K	LYS320
K	TYR411
K	HOH2173

site_id	JC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE K 42

Chain	Residue
K	ASN449
K	LYS451
K	ASP543
K	GLU564
K	GLN567
K	HOH2666
L	SER254

site_id	JC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE K 50

Chain	Residue
K	LEU94
K	ASP95
K	THR97

site_id	JC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE K 52

Chain	Residue
K	SER517
K	LYS518
K	VAL524
K	TRP525

site_id	KC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE K 55

Chain	Residue
J	GLU454
J	GLY456
J	HOH4241
K	ASP394
K	LEU395
K	HOH2810

site_id	KC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 1001

Chain	Residue
L	LYS374
L	ASP379
L	ASP399
L	GLU461
L	HOH4266

site_id	KC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 L 1002

Chain	Residue
L	LYS374
L	ALA460
L	GLU461
L	GLY462
L	ARG463
L	LEU487
L	HOH4266

site_id	KC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE L 1

Chain	Residue
L	TYR103
L	ASN104
L	HIS108
L	LYS320
L	TYR411
L	HOH4243

site_id	KC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE L 25

Chain	Residue
J	SER254
L	ASN449
L	LYS451
L	GLU564

site_id	KC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE L 29

Chain	Residue
L	LEU514
L	SER517
L	VAL524
L	TRP525
L	HOH4242

site_id	KC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE L 56

Chain	Residue
L	TYR103
L	GLU316
L	LYS320
L	HOH3139

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE L 59

Chain	Residue
L	GLY390
L	MET392
L	PHE398
L	THR486
L	GLY489
L	LEU492

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN457-LEU464

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P00727

Chain	Residue	Details
A	LYS386
E	ARG463
F	LYS386
F	ARG463
G	LYS386
G	ARG463
H	LYS386
H	ARG463
I	LYS386
I	ARG463
J	LYS386
A	ARG463
J	ARG463
K	LYS386
K	ARG463
L	LYS386
L	ARG463
B	LYS386
B	ARG463
C	LYS386
C	ARG463
D	LYS386
D	ARG463
E	LYS386

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:20133789, ECO:0000269\|PubMed:21844374, ECO:0000269\|PubMed:23713488, ECO:0000269\|PubMed:25299353, ECO:0000269\|PubMed:25645579, ECO:0000269\|PubMed:35691342, ECO:0000269\|Ref.13, ECO:0000312\|PDB:3T8W, ECO:0007744\|PDB:3KQX, ECO:0007744\|PDB:3KQZ, ECO:0007744\|PDB:3KR4, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N, ECO:0007744\|PDB:4R6T, ECO:0007744\|PDB:4R76, ECO:0007744\|PDB:4R7M, ECO:0007744\|PDB:4X2T, ECO:0007744\|PDB:7RIE, ECO:0007744\|PDB:7T3V

Chain	Residue	Details
A	LYS374
D	LYS374
D	ASP379
D	GLU461
E	LYS374
E	ASP379
E	GLU461
F	LYS374
F	ASP379
F	GLU461
G	LYS374
A	ASP379
G	ASP379
G	GLU461
H	LYS374
H	ASP379
H	GLU461
I	LYS374
I	ASP379
I	GLU461
J	LYS374
J	ASP379
A	GLU461
J	GLU461
K	LYS374
K	ASP379
K	GLU461
L	LYS374
L	ASP379
L	GLU461
B	LYS374
B	ASP379
B	GLU461
C	LYS374
C	ASP379
C	GLU461

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:20133789, ECO:0000305\|PubMed:23713488, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N

Chain	Residue	Details
A	LYS386
J	LYS386
K	LYS386
L	LYS386
B	LYS386
C	LYS386
D	LYS386
E	LYS386
F	LYS386
G	LYS386
H	LYS386
I	LYS386

site_id	SWS_FT_FI4
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:35691342, ECO:0007744\|PDB:7SRV

Chain	Residue	Details
A	ASP394
D	ASP394
D	MET396
D	ASP399
E	ASP394
E	MET396
E	ASP399
F	ASP394
F	MET396
F	ASP399
G	ASP394
A	MET396
G	MET396
G	ASP399
H	ASP394
H	MET396
H	ASP399
I	ASP394
I	MET396
I	ASP399
J	ASP394
J	MET396
A	ASP399
J	ASP399
K	ASP394
K	MET396
K	ASP399
L	ASP394
L	MET396
L	ASP399
B	ASP394
B	MET396
B	ASP399
C	ASP394
C	MET396
C	ASP399

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:20133789, ECO:0000269\|PubMed:21844374, ECO:0000269\|PubMed:23713488, ECO:0000269\|PubMed:25299353, ECO:0000269\|PubMed:25645579, ECO:0000269\|PubMed:35691342, ECO:0000269\|Ref.13, ECO:0000312\|PDB:3KQZ, ECO:0000312\|PDB:3T8W, ECO:0007744\|PDB:3KR4, ECO:0007744\|PDB:3KR5, ECO:0007744\|PDB:4K3N, ECO:0007744\|PDB:4R6T, ECO:0007744\|PDB:4R76, ECO:0007744\|PDB:4R7M, ECO:0007744\|PDB:4X2T, ECO:0007744\|PDB:7RIE, ECO:0007744\|PDB:7T3V

Chain	Residue	Details
A	ASP459
J	ASP459
K	ASP459
L	ASP459
B	ASP459
C	ASP459
D	ASP459
E	ASP459
F	ASP459
G	ASP459
H	ASP459
I	ASP459

site_id	SWS_FT_FI6
Number of Residues	12
Details	SITE: Essential for hexamer stabilization => ECO:0000269\|PubMed:35691342

Chain	Residue	Details
A	LYS386
J	LYS386
K	LYS386
L	LYS386
B	LYS386
C	LYS386
D	LYS386
E	LYS386
F	LYS386
G	LYS386
H	LYS386
I	LYS386

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)