3KNV

Crystal structure of the RING and first zinc finger domains of TRAF2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0005829	cellular_component	cytosol
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS49
A	HIS51
A	CYS69
A	CYS72

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 202

Chain	Residue
A	CYS34
A	CYS37
A	CYS54
A	CYS57

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 203

Chain	Residue
A	CYS112
A	HIS125
A	CYS129
A	CYS107

---

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHrYCsfCL

Chain	Residue	Details
A	CYS49-LEU58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"19150425","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19150425","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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