3KLF

Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
E	0003676	molecular_function	nucleic acid binding
E	0003964	molecular_function	RNA-directed DNA polymerase activity
E	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
E	0006278	biological_process	RNA-templated DNA biosynthetic process
F	0003964	molecular_function	RNA-directed DNA polymerase activity
F	0006278	biological_process	RNA-templated DNA biosynthetic process
I	0003676	molecular_function	nucleic acid binding
I	0003964	molecular_function	RNA-directed DNA polymerase activity
I	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
I	0006278	biological_process	RNA-templated DNA biosynthetic process
J	0003964	molecular_function	RNA-directed DNA polymerase activity
J	0006278	biological_process	RNA-templated DNA biosynthetic process
M	0003676	molecular_function	nucleic acid binding
M	0003964	molecular_function	RNA-directed DNA polymerase activity
M	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
M	0006278	biological_process	RNA-templated DNA biosynthetic process
N	0003964	molecular_function	RNA-directed DNA polymerase activity
N	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 600

Chain	Residue
A	ASP110
A	VAL111
A	ASP185
A	ZP4823

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 602

Chain	Residue
A	ASP443
A	GLY444
A	ASP498
A	ASP549
A	HOH567

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ZP4 A 823

Chain	Residue
A	LYS65
A	ARG72
A	ASP110
A	VAL111
A	GLY112
A	ASP113
A	ALA114
A	TYR115
A	PHE116
A	GLN151
A	MET184
A	ASP185
A	LYS219
A	HOH560
A	MG600
C	DA705
D	2DA822

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 429

Chain	Residue
B	ARG78
B	GLU79
B	LYS82
B	GLU413

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 600

Chain	Residue
E	ASP110
E	VAL111
E	ASP185
E	ZP4823

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 602

Chain	Residue
E	ASP443
E	GLY444
E	ASP498

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ZP4 E 823

Chain	Residue
E	LYS65
E	LYS66
E	ARG72
E	ASP110
E	VAL111
E	GLY112
E	ASP113
E	ALA114
E	TYR115
E	PHE116
E	GLN151
E	MET184
E	ASP185
E	HIS221
E	LEU228
E	MG600
G	DA705
H	2DA822

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL F 429

Chain	Residue
F	ARG78
F	GLU79
F	GLU413
F	HOH433

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG I 600

Chain	Residue
I	ASP110
I	VAL111
I	ASP185
I	ZP4823

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG I 602

Chain	Residue
I	ASP443
I	GLY444
I	GLU478
I	ASP498
I	HOH565

---

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ZP4 I 823

Chain	Residue
I	LYS65
I	ARG72
I	ASP110
I	VAL111
I	ASP113
I	ALA114
I	TYR115
I	PHE116
I	GLN151
I	MET184
I	ASP185
I	HIS221
I	LEU228
I	HOH564
I	MG600
K	DA705
L	2DA822

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG M 600

Chain	Residue
M	ASP110
M	VAL111
M	GLY112
M	ASP185
M	ZP4823

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG M 602

Chain	Residue
M	ASP443
M	GLU478
M	ASP498
M	HOH558

---

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ZP4 M 823

Chain	Residue
M	ALA114
M	TYR115
M	PHE116
M	GLN151
M	MET184
M	ASP185
M	LYS219
M	MG600
O	DA705
P	2DA822
M	LYS65
M	ARG72
M	ASP110
M	VAL111
M	ASP113

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	760
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"RT 'primer grip'"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	128
Details	Motif: {"description":"Tryptophan repeat motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Cleavage; by viral protease; partial"}

Chain

Residue

Details

---