3KK1

HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 561

Chain	Residue
A	ARG206
A	GLY436
A	ASN460
A	ARG461
A	HOH573
B	ALA288

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 562

Chain	Residue
A	GLN340

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 600

Chain	Residue
A	ASP185
A	914825
A	ASP110
A	VAL111

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	ASP443
A	GLU478
A	ASP498

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 914 A 825

Chain	Residue
A	LYS65
A	LYS70
A	ARG72
A	ASP110
A	VAL111
A	GLY112
A	ASP113
A	ALA114
A	TYR115
A	GLN151
A	ASP185
A	LYS219
A	HOH581
A	MG600
A	HOH625
P	DOC822
T	DT705
T	DG706

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 P 2

Chain	Residue
P	HOH115
P	DG816
P	DG817
T	DC711

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12206668","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain

Residue

Details

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