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3KFU

Crystal structure of the transamidosome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004815molecular_functionaspartate-tRNA ligase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006418biological_processtRNA aminoacylation for protein translation
A0006422biological_processaspartyl-tRNA aminoacylation
A0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
A0050560molecular_functionaspartate-tRNA(Asn) ligase activity
B0000166molecular_functionnucleotide binding
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004815molecular_functionaspartate-tRNA ligase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006412biological_processtranslation
B0006418biological_processtRNA aminoacylation for protein translation
B0006422biological_processaspartyl-tRNA aminoacylation
B0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
B0050560molecular_functionaspartate-tRNA(Asn) ligase activity
C0000166molecular_functionnucleotide binding
C0003676molecular_functionnucleic acid binding
C0003723molecular_functionRNA binding
C0004812molecular_functionaminoacyl-tRNA ligase activity
C0004815molecular_functionaspartate-tRNA ligase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006412biological_processtranslation
C0006418biological_processtRNA aminoacylation for protein translation
C0006422biological_processaspartyl-tRNA aminoacylation
C0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
C0050560molecular_functionaspartate-tRNA(Asn) ligase activity
D0000166molecular_functionnucleotide binding
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0004812molecular_functionaminoacyl-tRNA ligase activity
D0004815molecular_functionaspartate-tRNA ligase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006412biological_processtranslation
D0006418biological_processtRNA aminoacylation for protein translation
D0006422biological_processaspartyl-tRNA aminoacylation
D0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
D0050560molecular_functionaspartate-tRNA(Asn) ligase activity
E0003824molecular_functioncatalytic activity
E0005524molecular_functionATP binding
E0006412biological_processtranslation
E0016874molecular_functionligase activity
E0030956cellular_componentglutamyl-tRNA(Gln) amidotransferase complex
E0050567molecular_functionglutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
F0003824molecular_functioncatalytic activity
F0016874molecular_functionligase activity
F0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
G0005524molecular_functionATP binding
G0006412biological_processtranslation
G0006450biological_processregulation of translational fidelity
G0016874molecular_functionligase activity
G0050566molecular_functionasparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
G0050567molecular_functionglutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
G0070681biological_processglutaminyl-tRNAGln biosynthesis via transamidation
H0003824molecular_functioncatalytic activity
H0005524molecular_functionATP binding
H0006412biological_processtranslation
H0016874molecular_functionligase activity
H0030956cellular_componentglutamyl-tRNA(Gln) amidotransferase complex
H0050567molecular_functionglutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
I0003824molecular_functioncatalytic activity
I0016874molecular_functionligase activity
I0016884molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor
J0005524molecular_functionATP binding
J0006412biological_processtranslation
J0006450biological_processregulation of translational fidelity
J0016874molecular_functionligase activity
J0050566molecular_functionasparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
J0050567molecular_functionglutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
J0070681biological_processglutaminyl-tRNAGln biosynthesis via transamidation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 673
ChainResidue
FCYS22
FCYS24
FCYS38
FCYS41

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG F 674
ChainResidue
FHOH677
FHIS11
FGLU120
FGLU146
FHOH675
FHOH676

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN I 467
ChainResidue
ICYS22
ICYS24
ICYS38
ICYS41

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG I 468
ChainResidue
IHIS11
IGLU120
IGLU146
IHOH469
IHOH470
IHOH471

Functional Information from PROSITE/UniProt
site_idPS00571
Number of Residues32
DetailsAMIDASES Amidases signature. GGSSGGsAAaLAadlaplAlGsDtGgSVRqPA
ChainResidueDetails
EGLY139-ALA170

site_idPS01234
Number of Residues15
DetailsGATB Glutamyl-tRNA(Gln) amidotransferase subunit B signature. LNRagsPLIELvTeP
ChainResidueDetails
FLEU137-PRO151

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000255|HAMAP-Rule:MF_00120
ChainResidueDetails
ELYS66
BARG209
BGLU345
BSER348
BARG352
BGLY393
CGLU158
CARG201
CARG209
CGLU345
CSER348
ESER141
CARG352
CGLY393
DGLU158
DARG201
DARG209
DGLU345
DSER348
DARG352
DGLY393
HLYS66
HSER141
ASER348
AARG352
AGLY393
BGLU158
BARG201

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Acyl-ester intermediate => ECO:0000255|HAMAP-Rule:MF_00120
ChainResidueDetails
ESER165
CGLN44
CASN68
CGLU76
DARG26
DGLN44
DASN68
DGLU76
HSER165
AASN68
AGLU76
BARG26
BGLN44
BASN68
BGLU76
CARG26

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Important for tRNA non-discrimination => ECO:0000255|HAMAP-Rule:MF_02075
ChainResidueDetails
APRO72
BPRO72
CPRO72
DPRO72

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PDB entries from 2024-11-06

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