Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 901 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| A | HOH2040 |
| A | HOH2159 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 902 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 903 |
| Chain | Residue |
| A | ASP179 |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 904 |
| Chain | Residue |
| A | ALA161 |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| A | HOH2007 |
| A | HOH2266 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 905 |
| Chain | Residue |
| A | ASP128 |
| A | ASP203 |
| A | GLU205 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 3EK A 801 |
| Chain | Residue |
| A | LYS140 |
| A | ASN215 |
| A | PHE217 |
| A | LEU218 |
| A | VAL219 |
| A | HIS222 |
| A | ALA238 |
| A | LEU239 |
| A | PHE241 |
| A | ILE243 |
| A | TYR244 |
| A | THR245 |
| A | TYR246 |
| A | THR247 |
| A | LYS249 |
| A | SER250 |
| A | PRO255 |
| A | HOH2039 |
| A | HOH2062 |
| A | HOH2065 |
| A | HOH2094 |
| A | HOH2146 |
| A | HOH2208 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 901 |
| Chain | Residue |
| B | HIS222 |
| B | HIS226 |
| B | HIS232 |
| B | HOH2079 |
| B | HOH2130 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 902 |
| Chain | Residue |
| B | HIS172 |
| B | ASP174 |
| B | HIS187 |
| B | HIS200 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 903 |
| Chain | Residue |
| B | ASP179 |
| B | GLY180 |
| B | SER182 |
| B | LEU184 |
| B | ASP202 |
| B | GLU205 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 904 |
| Chain | Residue |
| B | ALA161 |
| B | ASP162 |
| B | ASN194 |
| B | GLY196 |
| B | ASP198 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 905 |
| Chain | Residue |
| B | ASP128 |
| B | GLU205 |
| B | THR206 |
| B | HOH2254 |
| site_id | BC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 3EK B 801 |
| Chain | Residue |
| B | LYS140 |
| B | ASN215 |
| B | PHE217 |
| B | LEU218 |
| B | VAL219 |
| B | HIS222 |
| B | ALA238 |
| B | LEU239 |
| B | PHE241 |
| B | PRO242 |
| B | ILE243 |
| B | TYR244 |
| B | THR245 |
| B | TYR246 |
| B | THR247 |
| B | LYS249 |
| B | SER250 |
| B | PRO255 |
| B | HOH2008 |
| B | HOH2101 |
| B | HOH2149 |
| B | HOH2166 |
| B | HOH2244 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS222 | |
| B | HIS222 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | PRO127 | |
| A | PHE201 | |
| A | ASP202 | |
| A | ASP204 | |
| B | PRO127 | |
| B | ALA161 | |
| B | PHE178 | |
| B | ASP179 | |
| B | PRO181 | |
| B | GLY183 | |
| B | PRO193 | |
| A | ALA161 | |
| B | TYR195 | |
| B | GLY197 | |
| B | PHE201 | |
| B | ASP202 | |
| B | ASP204 | |
| A | PHE178 | |
| A | ASP179 | |
| A | PRO181 | |
| A | GLY183 | |
| A | PRO193 | |
| A | TYR195 | |
| A | GLY197 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | GLU171 | |
| B | GLY173 | |
| B | ALA186 | |
| B | ALA199 | |
| B | ALA221 | |
| B | GLY225 | |
| B | ASP231 | |
| B | LEU239 | |
| A | GLY173 | |
| A | ALA186 | |
| A | ALA199 | |
| A | ALA221 | |
| A | GLY225 | |
| A | ASP231 | |
| A | LEU239 | |
| B | GLU171 | |
| Chain | Residue | Details |
| A | MET116 | |
| B | MET116 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU151 | |
| B | LEU151 | |
