3KED

Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 875

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	DAB880

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DAB A 880

Chain	Residue
A	HIS297
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	TYR381
A	ZN875
A	MLA991
A	GLU121
A	MET260
A	ALA262
A	MET263
A	GLU264

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 951

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	HOH949
A	HOH1126

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 952

Chain	Residue
A	ASP452
A	HOH1210

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 970

Chain	Residue
A	LEU532
A	TRP546
A	LEU554
A	ASP566
A	SER570

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 971

Chain	Residue
A	SER63
A	VAL64
A	TRP71
A	TRP74
A	ARG669
A	VAL670
A	GLU671
A	GOL972
A	GOL975
A	HOH980

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 972

Chain	Residue
A	VAL62
A	SER63
A	TRP74
A	ARG669
A	GLU671
A	GOL971

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 973

Chain	Residue
A	LEU378
A	TYR381
A	GLU382
A	MLA991

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 974

Chain	Residue
A	ARG681
A	ALA707
A	ASN708
A	ASN709
A	ASP712
A	HOH1290

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 975

Chain	Residue
A	THR72
A	TRP74
A	VAL670
A	GLU671
A	GOL971
A	HOH1222

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 976

Chain	Residue
A	HIS11
A	GLN467
A	ARG468
A	THR469
A	GLN479
A	PRO480

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 977

Chain	Residue
A	GLU123
A	ASP312
A	TRP313
A	PHE314

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 978

Chain	Residue
A	GLU409
A	ASP412
A	LEU589
A	SER590
A	LEU591
A	HOH1343
A	HOH1344

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MLA A 990

Chain	Residue
A	ARG641
A	GLU642
A	THR645
A	ARG686
A	ALA722
A	HOH1186
A	HOH1283

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MLA A 991

Chain	Residue
A	ARG293
A	ASP327
A	TYR381
A	DAB880
A	GOL973

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLA A 992

Chain	Residue
A	GLU69
A	PRO70
A	TRP71
A	THR72
A	PRO224
A	ARG279
A	THR280
A	TYR288
A	HOH994

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:16885166, ECO:0000305|PubMed:18416562, ECO:0000305|PubMed:19622865

Chain	Residue	Details
A	GLU298

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	HIS301
A	GLU320
A	GLU121
A	GLY261
A	HIS297

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305

Chain	Residue	Details
A	TYR381

---