3KED
Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 875 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | DAB880 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DAB A 880 |
| Chain | Residue |
| A | HIS297 |
| A | GLU298 |
| A | HIS301 |
| A | LYS319 |
| A | GLU320 |
| A | TYR381 |
| A | ZN875 |
| A | MLA991 |
| A | GLU121 |
| A | MET260 |
| A | ALA262 |
| A | MET263 |
| A | GLU264 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 951 |
| Chain | Residue |
| A | SER332 |
| A | ASP333 |
| A | GLY335 |
| A | HOH949 |
| A | HOH1126 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 952 |
| Chain | Residue |
| A | ASP452 |
| A | HOH1210 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 970 |
| Chain | Residue |
| A | LEU532 |
| A | TRP546 |
| A | LEU554 |
| A | ASP566 |
| A | SER570 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 971 |
| Chain | Residue |
| A | SER63 |
| A | VAL64 |
| A | TRP71 |
| A | TRP74 |
| A | ARG669 |
| A | VAL670 |
| A | GLU671 |
| A | GOL972 |
| A | GOL975 |
| A | HOH980 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 972 |
| Chain | Residue |
| A | VAL62 |
| A | SER63 |
| A | TRP74 |
| A | ARG669 |
| A | GLU671 |
| A | GOL971 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 973 |
| Chain | Residue |
| A | LEU378 |
| A | TYR381 |
| A | GLU382 |
| A | MLA991 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 974 |
| Chain | Residue |
| A | ARG681 |
| A | ALA707 |
| A | ASN708 |
| A | ASN709 |
| A | ASP712 |
| A | HOH1290 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 975 |
| Chain | Residue |
| A | THR72 |
| A | TRP74 |
| A | VAL670 |
| A | GLU671 |
| A | GOL971 |
| A | HOH1222 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 976 |
| Chain | Residue |
| A | HIS11 |
| A | GLN467 |
| A | ARG468 |
| A | THR469 |
| A | GLN479 |
| A | PRO480 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 977 |
| Chain | Residue |
| A | GLU123 |
| A | ASP312 |
| A | TRP313 |
| A | PHE314 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 978 |
| Chain | Residue |
| A | GLU409 |
| A | ASP412 |
| A | LEU589 |
| A | SER590 |
| A | LEU591 |
| A | HOH1343 |
| A | HOH1344 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLA A 990 |
| Chain | Residue |
| A | ARG641 |
| A | GLU642 |
| A | THR645 |
| A | ARG686 |
| A | ALA722 |
| A | HOH1186 |
| A | HOH1283 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLA A 991 |
| Chain | Residue |
| A | ARG293 |
| A | ASP327 |
| A | TYR381 |
| A | DAB880 |
| A | GOL973 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MLA A 992 |
| Chain | Residue |
| A | GLU69 |
| A | PRO70 |
| A | TRP71 |
| A | THR72 |
| A | PRO224 |
| A | ARG279 |
| A | THR280 |
| A | TYR288 |
| A | HOH994 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
