3KDF

X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0007346	biological_process	regulation of mitotic cell cycle
A	0031981	cellular_component	nuclear lumen
A	0035861	cellular_component	site of double-strand break
A	0042127	biological_process	regulation of cell population proliferation
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005662	cellular_component	DNA replication factor A complex
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006310	biological_process	DNA recombination
C	0007346	biological_process	regulation of mitotic cell cycle
C	0031981	cellular_component	nuclear lumen
C	0035861	cellular_component	site of double-strand break
C	0042127	biological_process	regulation of cell population proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 122

Chain	Residue
A	LEU55
A	MSE56
A	GLU57
A	CYS81
A	HOH259

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 122

Chain	Residue
C	GLN111
C	PHE112
C	HOH321
A	GLU101
A	HOH244
C	ASP108
C	PHE109

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO D 3

Chain	Residue
C	GLN86
C	PHE87
C	LYS88
D	GLU123
D	THR124
D	TYR125
D	MSE152
D	HOH175

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 123

Chain	Residue
A	GLN86
A	PHE87
A	LYS88
B	GLU123
B	TYR125
B	MSE152

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 7

Chain	Residue
D	MSE147
D	PRO148
D	GLU150
D	GLU154

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 123

Chain	Residue
C	TYR84
C	HOH414

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 124

Chain	Residue
A	ASP108
C	LYS104
C	ASP108

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	148
Details	DNA_BIND: OB

Chain	Residue	Details
D	VAL74-PRO148
B	VAL74-PRO148

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068

Chain	Residue	Details
A	LYS23
A	LYS39
A	LYS88
C	LYS23
C	LYS39
C	LYS88

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