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3K72

Structure of integrin alphaX beta2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008305cellular_componentintegrin complex
A0009887biological_processanimal organ morphogenesis
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0030335biological_processpositive regulation of cell migration
A0030667cellular_componentsecretory granule membrane
A0030971molecular_functionreceptor tyrosine kinase binding
A0031643biological_processpositive regulation of myelination
A0033627biological_processcell adhesion mediated by integrin
A0034113biological_processheterotypic cell-cell adhesion
A0034689cellular_componentintegrin alphaX-beta2 complex
A0038023molecular_functionsignaling receptor activity
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
A0070821cellular_componenttertiary granule membrane
A0098609biological_processcell-cell adhesion
A0101003cellular_componentficolin-1-rich granule membrane
A1905956biological_processpositive regulation of endothelial tube morphogenesis
B0001540molecular_functionamyloid-beta binding
B0001774biological_processmicroglial cell activation
B0001851molecular_functioncomplement component C3b binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006898biological_processreceptor-mediated endocytosis
B0006909biological_processphagocytosis
B0006911biological_processphagocytosis, engulfment
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007155biological_processcell adhesion
B0007159biological_processleukocyte cell-cell adhesion
B0007160biological_processcell-matrix adhesion
B0007229biological_processintegrin-mediated signaling pathway
B0007267biological_processcell-cell signaling
B0008305cellular_componentintegrin complex
B0008360biological_processregulation of cell shape
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0019901molecular_functionprotein kinase binding
B0030369molecular_functionICAM-3 receptor activity
B0030593biological_processneutrophil chemotaxis
B0031072molecular_functionheat shock protein binding
B0031623biological_processreceptor internalization
B0032930biological_processpositive regulation of superoxide anion generation
B0034113biological_processheterotypic cell-cell adhesion
B0034687cellular_componentintegrin alphaL-beta2 complex
B0034688cellular_componentintegrin alphaM-beta2 complex
B0034689cellular_componentintegrin alphaX-beta2 complex
B0035579cellular_componentspecific granule membrane
B0035987biological_processendodermal cell differentiation
B0038024molecular_functioncargo receptor activity
B0043113biological_processreceptor clustering
B0043235cellular_componentreceptor complex
B0043315biological_processpositive regulation of neutrophil degranulation
B0044853cellular_componentplasma membrane raft
B0045121cellular_componentmembrane raft
B0045963biological_processnegative regulation of dopamine metabolic process
B0046872molecular_functionmetal ion binding
B0050730biological_processregulation of peptidyl-tyrosine phosphorylation
B0050839molecular_functioncell adhesion molecule binding
B0070062cellular_componentextracellular exosome
B0070821cellular_componenttertiary granule membrane
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0090314biological_processpositive regulation of protein targeting to membrane
B0097242biological_processamyloid-beta clearance
B0098609biological_processcell-cell adhesion
B0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
B0101003cellular_componentficolin-1-rich granule membrane
B1903561cellular_componentextracellular vesicle
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1990266biological_processneutrophil migration
B2000363biological_processpositive regulation of prostaglandin-E synthase activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007229biological_processintegrin-mediated signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0008305cellular_componentintegrin complex
C0009887biological_processanimal organ morphogenesis
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010628biological_processpositive regulation of gene expression
C0016020cellular_componentmembrane
C0030335biological_processpositive regulation of cell migration
C0030667cellular_componentsecretory granule membrane
C0030971molecular_functionreceptor tyrosine kinase binding
C0031643biological_processpositive regulation of myelination
C0033627biological_processcell adhesion mediated by integrin
C0034113biological_processheterotypic cell-cell adhesion
C0034689cellular_componentintegrin alphaX-beta2 complex
C0038023molecular_functionsignaling receptor activity
C0045766biological_processpositive regulation of angiogenesis
C0046872molecular_functionmetal ion binding
C0051607biological_processdefense response to virus
C0070821cellular_componenttertiary granule membrane
C0098609biological_processcell-cell adhesion
C0101003cellular_componentficolin-1-rich granule membrane
C1905956biological_processpositive regulation of endothelial tube morphogenesis
D0001540molecular_functionamyloid-beta binding
D0001774biological_processmicroglial cell activation
D0001851molecular_functioncomplement component C3b binding
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006898biological_processreceptor-mediated endocytosis
D0006909biological_processphagocytosis
D0006911biological_processphagocytosis, engulfment
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0007155biological_processcell adhesion
D0007159biological_processleukocyte cell-cell adhesion
D0007160biological_processcell-matrix adhesion
D0007229biological_processintegrin-mediated signaling pathway
D0007267biological_processcell-cell signaling
D0008305cellular_componentintegrin complex
D0008360biological_processregulation of cell shape
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0016020cellular_componentmembrane
D0019901molecular_functionprotein kinase binding
D0030369molecular_functionICAM-3 receptor activity
D0030593biological_processneutrophil chemotaxis
D0031072molecular_functionheat shock protein binding
D0031623biological_processreceptor internalization
D0032930biological_processpositive regulation of superoxide anion generation
D0034113biological_processheterotypic cell-cell adhesion
D0034687cellular_componentintegrin alphaL-beta2 complex
D0034688cellular_componentintegrin alphaM-beta2 complex
D0034689cellular_componentintegrin alphaX-beta2 complex
D0035579cellular_componentspecific granule membrane
D0035987biological_processendodermal cell differentiation
D0038024molecular_functioncargo receptor activity
D0043113biological_processreceptor clustering
D0043235cellular_componentreceptor complex
D0043315biological_processpositive regulation of neutrophil degranulation
D0044853cellular_componentplasma membrane raft
D0045121cellular_componentmembrane raft
D0045963biological_processnegative regulation of dopamine metabolic process
D0046872molecular_functionmetal ion binding
D0050730biological_processregulation of peptidyl-tyrosine phosphorylation
D0050839molecular_functioncell adhesion molecule binding
D0070062cellular_componentextracellular exosome
D0070821cellular_componenttertiary granule membrane
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0090314biological_processpositive regulation of protein targeting to membrane
D0097242biological_processamyloid-beta clearance
D0098609biological_processcell-cell adhesion
D0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
D0101003cellular_componentficolin-1-rich granule membrane
D1903561cellular_componentextracellular vesicle
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D1990266biological_processneutrophil migration
D2000363biological_processpositive regulation of prostaglandin-E synthase activity
Functional Information from PROSITE/UniProt
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCdtGYigknce..C
ChainResidueDetails
BCYS448-CYS461
BCYS540-CYS553
BCYS579-CYS593

site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
ChainResidueDetails
BCYS448-CYS459
BCYS540-CYS551

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGl..GdCvCgqClC
ChainResidueDetails
BCYS484-CYS497
BCYS527-CYS542
BCYS568-CYS581

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1354
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN1-ASP678
DGLN1-ASP678
ASER142
AASP240
CASP138
CSER140
CSER142
CASP240

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BSER114
AASP578
AASP582
CASP447
CASP449
CASP451
CASP455
CASP511
CASN513
CASP515
CASP519
BSER116
CASP574
CASP578
CASP582
BGLU212
DSER114
DSER116
DGLU212
AASP515
AASP519
AASP574

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
ChainResidueDetails
BASP119
DASP119
AASN678
AASN716
CASN42
CASN373
CASN678
CASN716

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP120
DASP120
AASN1031
CASN70
CASN920
CASN1031

site_idSWS_FT_FI5
Number of Residues8
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP151
BASN207
BASP209
BPRO211
DASP151
DASN207
DASP209
DPRO211

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP242
DASP242

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH
ChainResidueDetails
BGLU325
DGLU325

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816
ChainResidueDetails
BGLN1
DGLN1

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN28
DASN28

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASN94
DASN94

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN190
DASN190

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN232
BASN479
DASN232
DASN479

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASN620
DASN620

219140

PDB entries from 2024-05-01

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