3K5T
Crystal structure of human diamine oxidase in space group C2221
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005923 | cellular_component | bicellular tight junction |
| A | 0008131 | molecular_function | primary amine oxidase activity |
| A | 0008201 | molecular_function | heparin binding |
| A | 0009308 | biological_process | amine metabolic process |
| A | 0009445 | biological_process | putrescine metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048038 | molecular_function | quinone binding |
| A | 0050232 | molecular_function | putrescine oxidase activity |
| A | 0052597 | molecular_function | diamine oxidase activity |
| A | 0052598 | molecular_function | histamine oxidase activity |
| A | 0052599 | molecular_function | methylputrescine oxidase activity |
| A | 0052600 | molecular_function | propane-1,3-diamine oxidase activity |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS01164 |
| Number of Residues | 14 |
| Details | COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. LVLrttsTvyNYDY |
| Chain | Residue | Details |
| A | LEU450-TYR463 |
| site_id | PS01165 |
| Number of Residues | 14 |
| Details | COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TvGflHIphsEDiP |
| Chain | Residue | Details |
| A | THR670-PRO683 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:19764817 |
| Chain | Residue | Details |
| A | ASP373 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Schiff-base intermediate with substrate; via topaquinone => ECO:0000269|PubMed:19764817, ECO:0007744|PDB:3HI7, ECO:0007744|PDB:3HIG, ECO:0007744|PDB:3HII, ECO:0007744|PDB:3K5T |
| Chain | Residue | Details |
| A | TPQ461 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19764817, ECO:0007744|PDB:3HI7, ECO:0007744|PDB:3HIG, ECO:0007744|PDB:3HII, ECO:0007744|PDB:3K5T, ECO:0007744|PDB:3MPH |
| Chain | Residue | Details |
| A | ASP519 | |
| A | LEU520 | |
| A | ASP521 | |
| A | GLU562 | |
| A | PHE653 | |
| A | ASN656 | |
| A | GLU658 | |
| A | ASP664 | |
| A | LEU665 | |
| A | HIS675 | |
| A | HIS510 | |
| A | HIS512 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 2',4',5'-topaquinone => ECO:0000269|PubMed:19764817 |
| Chain | Residue | Details |
| A | TPQ461 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19764817, ECO:0007744|PDB:3HI7, ECO:0007744|PDB:3HIG, ECO:0007744|PDB:3HII, ECO:0007744|PDB:3K5T, ECO:0007744|PDB:3MPH |
| Chain | Residue | Details |
| A | ASN538 | |
| A | ASN745 | |
| A | ASN110 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN168 |
