Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3K35

Crystal Structure of Human SIRT6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070403	molecular_function	NAD+ binding
B	0070403	molecular_function	NAD+ binding
C	0070403	molecular_function	NAD+ binding
D	0070403	molecular_function	NAD+ binding
E	0070403	molecular_function	NAD+ binding
F	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 317

Chain	Residue
A	CYS139
A	CYS142
A	CYS164
A	CYS175

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE APR A 1001

Chain	Residue
A	PHE62
A	ARG63
A	TRP69
A	GLN111
A	HIS131
A	GLY212
A	THR213
A	SER214
A	ILE217
A	ASN238
A	LEU239
A	GLN240
A	GLY254
A	TYR255
A	VAL256
A	HOH326
A	HOH356
A	HOH374
A	HOH487
A	HOH500
A	GLY50
A	ALA51
A	GLY52
A	THR55
A	ASP61

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 318

Chain	Residue
A	LYS31
A	ARG251
A	HIS253
A	HOH534

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 319

Chain	Residue
A	HIS66
A	ARG74
A	HOH740

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 320

Chain	Residue
A	HIS66
A	LYS79
A	HOH626

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 321

Chain	Residue
A	ARG203
A	ARG229
A	ARG230
A	HOH526
B	ARG106

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 317

Chain	Residue
B	CYS139
B	CYS142
B	CYS164
B	CYS175

site_id	AC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE APR B 2001

Chain	Residue
B	GLY50
B	ALA51
B	GLY52
B	THR55
B	ASP61
B	PHE62
B	ARG63
B	TRP69
B	GLN111
B	HIS131
B	GLY212
B	THR213
B	SER214
B	ILE217
B	ASN238
B	LEU239
B	GLN240
B	GLY254
B	TYR255
B	VAL256
B	HOH326
B	HOH327
B	HOH371
B	HOH388
B	HOH902

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 318

Chain	Residue
B	LYS31
B	ARG251
B	HIS253

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 319

Chain	Residue
B	VAL152
B	GLY153
B	THR160
B	ARG162
D	LYS294

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 317

Chain	Residue
C	CYS139
C	CYS142
C	CYS164
C	CYS175

site_id	BC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE APR C 3001

Chain	Residue
C	ASN238
C	LEU239
C	GLN240
C	GLY254
C	TYR255
C	VAL256
C	HOH326
C	HOH354
C	HOH372
C	HOH472
C	HOH612
C	HOH618
C	GLY50
C	ALA51
C	GLY52
C	THR55
C	ASP61
C	PHE62
C	ARG63
C	TRP69
C	GLN111
C	HIS131
C	GLY212
C	THR213
C	SER214
C	ILE217

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 318

Chain	Residue
C	ARG218
C	PRO219
C	ASN222
C	HOH366

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 317

Chain	Residue
D	CYS139
D	CYS142
D	CYS164
D	CYS175

site_id	BC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE APR D 4001

Chain	Residue
D	GLY50
D	ALA51
D	GLY52
D	THR55
D	ASP61
D	PHE62
D	ARG63
D	TRP69
D	GLN111
D	HIS131
D	GLY212
D	THR213
D	SER214
D	ILE217
D	ASN238
D	LEU239
D	GLN240
D	GLY254
D	TYR255
D	VAL256
D	HOH323
D	HOH333
D	HOH374
D	HOH1005

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 318

Chain	Residue
D	LYS31
D	ARG251
D	HIS253
D	HOH376
D	HOH778

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 319

Chain	Residue
D	HIS66
D	LYS79
D	HOH335
D	HOH499
D	HOH682
D	HOH734

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 317

Chain	Residue
E	CYS139
E	CYS142
E	CYS164
E	CYS175

site_id	CC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE APR E 5001

Chain	Residue
E	GLY50
E	ALA51
E	GLY52
E	THR55
E	ASP61
E	PHE62
E	ARG63
E	TRP69
E	GLN111
E	HIS131
E	GLY212
E	THR213
E	SER214
E	ILE217
E	ASN238
E	LEU239
E	GLN240
E	GLY254
E	TYR255
E	VAL256
E	HOH326
E	HOH343
E	HOH345
E	HOH468

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 318

Chain	Residue
E	HIS66
E	LYS79
E	HOH337
E	HOH341
E	HOH419

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 319

Chain	Residue
E	HIS66

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 317

Chain	Residue
F	CYS139
F	CYS142
F	CYS164
F	CYS175

site_id	CC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE APR F 6001

Chain	Residue
F	GLY50
F	ALA51
F	GLY52
F	THR55
F	ASP61
F	PHE62
F	ARG63
F	TRP69
F	GLN111
F	HIS131
F	GLY212
F	THR213
F	SER214
F	ILE217
F	ASN238
F	LEU239
F	GLN240
F	GLY254
F	TYR255
F	VAL256
F	HOH333
F	HOH381

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 318

Chain	Residue
F	LYS31
F	ARG251
F	HIS253

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 319

Chain	Residue
B	LYS294
D	ARG74
F	VAL152
F	GLY153
F	ARG162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00236, ECO:0000269\|PubMed:18337721, ECO:0000305\|PubMed:23552949, ECO:0000305\|PubMed:23892288, ECO:0000305\|PubMed:27322069, ECO:0000305\|PubMed:28406396

Chain	Residue	Details
A	HIS131
B	HIS131
C	HIS131
D	HIS131
E	HIS131
F	HIS131

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:21362626, ECO:0007744\|PDB:3K35, ECO:0007744\|PDB:3ZG6

Chain	Residue	Details
A	ALA51
B	ALA51
C	ALA51
D	ALA51
E	ALA51
F	ALA51

site_id	SWS_FT_FI3
Number of Residues	66
Details	BINDING: BINDING => ECO:0000269\|PubMed:23552949, ECO:0000305\|PubMed:21362626, ECO:0007744\|PDB:3K35, ECO:0007744\|PDB:3ZG6

Chain	Residue	Details
A	THR55
A	GLN240
A	VAL256
B	THR55
B	PHE62
B	ARG63
B	TRP69
B	GLN111
B	HIS131
B	GLY212
B	SER214
A	PHE62
B	ASN238
B	GLN240
B	VAL256
C	THR55
C	PHE62
C	ARG63
C	TRP69
C	GLN111
C	HIS131
C	GLY212
A	ARG63
C	SER214
C	ASN238
C	GLN240
C	VAL256
D	THR55
D	PHE62
D	ARG63
D	TRP69
D	GLN111
D	HIS131
A	TRP69
D	GLY212
D	SER214
D	ASN238
D	GLN240
D	VAL256
E	THR55
E	PHE62
E	ARG63
E	TRP69
E	GLN111
A	GLN111
E	HIS131
E	GLY212
E	SER214
E	ASN238
E	GLN240
E	VAL256
F	THR55
F	PHE62
F	ARG63
F	TRP69
A	HIS131
F	GLN111
F	HIS131
F	GLY212
F	SER214
F	ASN238
F	GLN240
F	VAL256
A	GLY212
A	SER214
A	ASN238

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00236, ECO:0000269\|PubMed:21362626, ECO:0000269\|PubMed:23552949, ECO:0000269\|PubMed:27990725, ECO:0007744\|PDB:3K35, ECO:0007744\|PDB:3PKI, ECO:0007744\|PDB:3PKJ, ECO:0007744\|PDB:3ZG6, ECO:0007744\|PDB:5MF6, ECO:0007744\|PDB:5MFP, ECO:0007744\|PDB:5MFZ, ECO:0007744\|PDB:5MGN

Chain	Residue	Details
A	CYS139
C	CYS142
C	CYS164
C	CYS175
D	CYS139
D	CYS142
D	CYS164
D	CYS175
E	CYS139
E	CYS142
E	CYS164
A	CYS142
E	CYS175
F	CYS139
F	CYS142
F	CYS164
F	CYS175
A	CYS164
A	CYS175
B	CYS139
B	CYS142
B	CYS164
B	CYS175
C	CYS139

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Formation of an covalent adduct with nitro-fatty acid activators => ECO:0000269\|PubMed:33122195

Chain	Residue	Details
A	CYS16
B	CYS16
C	CYS16
D	CYS16
E	CYS16
F	CYS16

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:27568560, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER8
B	SER8
C	SER8
D	SER8
E	SER8
F	SER8

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:32538779

Chain	Residue	Details
A	LYS31
B	LYS31
C	LYS31
D	LYS31
E	LYS31
F	LYS31

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR292
B	THR292
C	THR292
D	THR292
E	THR292
F	THR292

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER301
B	SER301
C	SER301
D	SER301
E	SER301
F	SER301

site_id	SWS_FT_FI10
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:24043303

Chain	Residue	Details
A	LYS168
F	LYS168
B	LYS168
C	LYS168
D	LYS168
E	LYS168

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)