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3JPX

EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001222molecular_functiontranscription corepressor binding
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0008047molecular_functionenzyme activator activity
A0021510biological_processspinal cord development
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0035098cellular_componentESC/E(Z) complex
A0042054molecular_functionhistone methyltransferase activity
A0042802molecular_functionidentical protein binding
A0045892biological_processnegative regulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY14-HIS18

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
ALEU206-ILE220

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsDNA_BIND:
ChainResidueDetails
BLYS16-M3L20

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393
ChainResidueDetails
BLYS16
ALYS197
ALYS268
ALYS284

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793
ChainResidueDetails
BM3L20

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
BM3L20

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PDB entries from 2024-07-24

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