3JC2
The structure of the mammalian Sec61 channel opened by a signal sequence
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0005048 | molecular_function | signal sequence binding |
| 1 | 0005783 | cellular_component | endoplasmic reticulum |
| 1 | 0005784 | cellular_component | Sec61 translocon complex |
| 1 | 0005789 | cellular_component | endoplasmic reticulum membrane |
| 1 | 0006613 | biological_process | cotranslational protein targeting to membrane |
| 1 | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| 1 | 0008320 | molecular_function | protein transmembrane transporter activity |
| 1 | 0015031 | biological_process | protein transport |
| 1 | 0016020 | cellular_component | membrane |
| 1 | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| 1 | 0039019 | biological_process | pronephric nephron development |
| 1 | 0043022 | molecular_function | ribosome binding |
| 1 | 0045047 | biological_process | protein targeting to ER |
| 1 | 0045048 | biological_process | protein insertion into ER membrane |
| 2 | 0005543 | molecular_function | phospholipid binding |
| 2 | 0005783 | cellular_component | endoplasmic reticulum |
| 2 | 0005789 | cellular_component | endoplasmic reticulum membrane |
| 2 | 0006605 | biological_process | protein targeting |
| 2 | 0006886 | biological_process | intracellular protein transport |
| 2 | 0008320 | molecular_function | protein transmembrane transporter activity |
| 2 | 0015031 | biological_process | protein transport |
| 2 | 0016020 | cellular_component | membrane |
| 2 | 0022406 | biological_process | membrane docking |
| 2 | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| 2 | 0043022 | molecular_function | ribosome binding |
| 2 | 0045047 | biological_process | protein targeting to ER |
| 2 | 0071261 | cellular_component | Ssh1 translocon complex |
Functional Information from PROSITE/UniProt
| site_id | PS00755 |
| Number of Residues | 20 |
| Details | SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL |
| Chain | Residue | Details |
| 1 | THR75-LEU94 |
| site_id | PS00756 |
| Number of Residues | 19 |
| Details | SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF |
| Chain | Residue | Details |
| 1 | LEU164-PHE182 |
| site_id | PS01067 |
| Number of Residues | 29 |
| Details | SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI |
| Chain | Residue | Details |
| 2 | PHE14-ILE42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT |
| Chain | Residue | Details |
| 2 | ILE36-ILE61 | |
| 1 | LYS98-ARG109 | |
| 1 | LEU168-SER177 | |
| 1 | GLY260-TYR285 | |
| 1 | ILE380-ALA420 | |
| 1 | GLU459-PHE476 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT |
| Chain | Residue | Details |
| 2 | ASN62-GLY68 | |
| 1 | GLY444-PHE458 | |
| 1 | ILE81-ALA97 | |
| 1 | ALA110-TYR131 | |
| 1 | LEU149-GLU167 | |
| 1 | GLY178-PHE196 | |
| 1 | LEU242-GLN259 | |
| 1 | THR286-GLN306 | |
| 1 | ASP357-TRP379 | |
| 1 | ALA421-PHE437 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60059 |
| Chain | Residue | Details |
| 2 | SER18 | |
| 1 | VAL132-CYS148 | |
| 1 | SER197-ASN241 | |
| 1 | MET307-GLU356 | |
| 1 | LEU438-SER443 |
