Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3JA6

Cryo-electron Tomography and All-atom Molecular Dynamics Simulations Reveal a Novel Kinase Conformational Switch in Bacterial Chemotaxis Signaling

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0019904	molecular_function	protein domain specific binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006935	biological_process	chemotaxis
B	0007165	biological_process	signal transduction
B	0019904	molecular_function	protein domain specific binding
C	0000155	molecular_function	phosphorelay sensor kinase activity
C	0000160	biological_process	phosphorelay signal transduction system
C	0004673	molecular_function	protein histidine kinase activity
C	0005737	cellular_component	cytoplasm
C	0006935	biological_process	chemotaxis
C	0007165	biological_process	signal transduction
C	0016310	biological_process	phosphorylation
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006935	biological_process	chemotaxis
D	0007165	biological_process	signal transduction
D	0019904	molecular_function	protein domain specific binding
E	0000155	molecular_function	phosphorelay sensor kinase activity
E	0000160	biological_process	phosphorelay signal transduction system
E	0004673	molecular_function	protein histidine kinase activity
E	0005737	cellular_component	cytoplasm
E	0006935	biological_process	chemotaxis
E	0007165	biological_process	signal transduction
E	0016310	biological_process	phosphorylation
E	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006935	biological_process	chemotaxis
F	0007165	biological_process	signal transduction
F	0019904	molecular_function	protein domain specific binding
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0006935	biological_process	chemotaxis
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0006935	biological_process	chemotaxis
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0006935	biological_process	chemotaxis
I	0007165	biological_process	signal transduction
I	0016020	cellular_component	membrane
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0006935	biological_process	chemotaxis
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
K	0004888	molecular_function	transmembrane signaling receptor activity
K	0006935	biological_process	chemotaxis
K	0007165	biological_process	signal transduction
K	0016020	cellular_component	membrane
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0006935	biological_process	chemotaxis
L	0007165	biological_process	signal transduction
L	0016020	cellular_component	membrane
M	0004888	molecular_function	transmembrane signaling receptor activity
M	0006935	biological_process	chemotaxis
M	0007165	biological_process	signal transduction
M	0016020	cellular_component	membrane
N	0004888	molecular_function	transmembrane signaling receptor activity
N	0006935	biological_process	chemotaxis
N	0007165	biological_process	signal transduction
N	0016020	cellular_component	membrane
O	0004888	molecular_function	transmembrane signaling receptor activity
O	0006935	biological_process	chemotaxis
O	0007165	biological_process	signal transduction
O	0016020	cellular_component	membrane
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0006935	biological_process	chemotaxis
P	0007165	biological_process	signal transduction
P	0016020	cellular_component	membrane
Q	0004888	molecular_function	transmembrane signaling receptor activity
Q	0006935	biological_process	chemotaxis
Q	0007165	biological_process	signal transduction
Q	0016020	cellular_component	membrane
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0006935	biological_process	chemotaxis
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Glutamate methyl ester (Gln) => ECO:0000269\|PubMed:16707700

Chain	Residue	Details
H	GLN274
J	GLN274
L	GLN274
N	GLN274
P	GLN274
R	GLN274

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Glutamate methyl ester (Glu) => ECO:0000269\|PubMed:16707700

Chain	Residue	Details
H	GLU281
P	GLU505
R	GLU281
R	GLU505
H	GLU505
J	GLU281
J	GLU505
L	GLU281
L	GLU505
N	GLU281
N	GLU505
P	GLU281

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Deamidated glutamine => ECO:0000269\|PubMed:16707700

Chain	Residue	Details
H	GLN498
J	GLN498
L	GLN498
N	GLN498
P	GLN498
R	GLN498

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 327

Chain	Residue	Details
C	ASN409	electrostatic stabiliser, hydrogen bond donor, metal ligand, steric role

site_id	MCSA2
Number of Residues	1
Details	M-CSA 327

Chain	Residue	Details
E	ASN409	electrostatic stabiliser, hydrogen bond donor, metal ligand, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)