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3J9P

Structure of the TRPA1 ion channel determined by electron cryo-microscopy

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006974biological_processDNA damage response
A0007166biological_processcell surface receptor signaling pathway
A0008643biological_processcarbohydrate transport
A0009409biological_processresponse to cold
A0009410biological_processresponse to xenobiotic stimulus
A0014070biological_processresponse to organic cyclic compound
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015267molecular_functionchannel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0030288cellular_componentouter membrane-bounded periplasmic space
A0032421cellular_componentstereocilium bundle
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0042542biological_processresponse to hydrogen peroxide
A0042597cellular_componentperiplasmic space
A0042802molecular_functionidentical protein binding
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0048265biological_processresponse to pain
A0050955biological_processthermoception
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
A0050974biological_processdetection of mechanical stimulus involved in sensory perception
A0051289biological_processprotein homotetramerization
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0070301biological_processcellular response to hydrogen peroxide
A0070588biological_processcalcium ion transmembrane transport
A0097604molecular_functiontemperature-gated cation channel activity
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
B0005216molecular_functionmonoatomic ion channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006974biological_processDNA damage response
B0007166biological_processcell surface receptor signaling pathway
B0008643biological_processcarbohydrate transport
B0009409biological_processresponse to cold
B0009410biological_processresponse to xenobiotic stimulus
B0014070biological_processresponse to organic cyclic compound
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015267molecular_functionchannel activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0019233biological_processsensory perception of pain
B0019722biological_processcalcium-mediated signaling
B0030288cellular_componentouter membrane-bounded periplasmic space
B0032421cellular_componentstereocilium bundle
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042542biological_processresponse to hydrogen peroxide
B0042597cellular_componentperiplasmic space
B0042802molecular_functionidentical protein binding
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0048265biological_processresponse to pain
B0050955biological_processthermoception
B0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
B0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
B0050974biological_processdetection of mechanical stimulus involved in sensory perception
B0051289biological_processprotein homotetramerization
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0070301biological_processcellular response to hydrogen peroxide
B0070588biological_processcalcium ion transmembrane transport
B0097604molecular_functiontemperature-gated cation channel activity
B1901982molecular_functionmaltose binding
B1990060cellular_componentmaltose transport complex
C0005216molecular_functionmonoatomic ion channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006974biological_processDNA damage response
C0007166biological_processcell surface receptor signaling pathway
C0008643biological_processcarbohydrate transport
C0009409biological_processresponse to cold
C0009410biological_processresponse to xenobiotic stimulus
C0014070biological_processresponse to organic cyclic compound
C0015144molecular_functioncarbohydrate transmembrane transporter activity
C0015267molecular_functionchannel activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0030288cellular_componentouter membrane-bounded periplasmic space
C0032421cellular_componentstereocilium bundle
C0034219biological_processcarbohydrate transmembrane transport
C0034289biological_processdetection of maltose stimulus
C0042542biological_processresponse to hydrogen peroxide
C0042597cellular_componentperiplasmic space
C0042802molecular_functionidentical protein binding
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0048265biological_processresponse to pain
C0050955biological_processthermoception
C0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
C0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
C0050974biological_processdetection of mechanical stimulus involved in sensory perception
C0051289biological_processprotein homotetramerization
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0060326biological_processcell chemotaxis
C0070301biological_processcellular response to hydrogen peroxide
C0070588biological_processcalcium ion transmembrane transport
C0097604molecular_functiontemperature-gated cation channel activity
C1901982molecular_functionmaltose binding
C1990060cellular_componentmaltose transport complex
D0005216molecular_functionmonoatomic ion channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006974biological_processDNA damage response
D0007166biological_processcell surface receptor signaling pathway
D0008643biological_processcarbohydrate transport
D0009409biological_processresponse to cold
D0009410biological_processresponse to xenobiotic stimulus
D0014070biological_processresponse to organic cyclic compound
D0015144molecular_functioncarbohydrate transmembrane transporter activity
D0015267molecular_functionchannel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0015768biological_processmaltose transport
D0016020cellular_componentmembrane
D0019233biological_processsensory perception of pain
D0019722biological_processcalcium-mediated signaling
D0030288cellular_componentouter membrane-bounded periplasmic space
D0032421cellular_componentstereocilium bundle
D0034219biological_processcarbohydrate transmembrane transport
D0034289biological_processdetection of maltose stimulus
D0042542biological_processresponse to hydrogen peroxide
D0042597cellular_componentperiplasmic space
D0042802molecular_functionidentical protein binding
D0042956biological_processmaltodextrin transmembrane transport
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0048265biological_processresponse to pain
D0050955biological_processthermoception
D0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0050974biological_processdetection of mechanical stimulus involved in sensory perception
D0051289biological_processprotein homotetramerization
D0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D0055085biological_processtransmembrane transport
D0060326biological_processcell chemotaxis
D0070301biological_processcellular response to hydrogen peroxide
D0070588biological_processcalcium ion transmembrane transport
D0097604molecular_functiontemperature-gated cation channel activity
D1901982molecular_functionmaltose binding
D1990060cellular_componentmaltose transport complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL
ChainResidueDetails
DASP468-LEU480

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
DPRO-286-ASN-269

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DHIS719-ASN739
AHIS719-ASN739
BHIS719-ASN739
CHIS719-ASN739

site_idSWS_FT_FI2
Number of Residues200
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
DILE740-SER767
BVAL824-HIS829
BASN893-PRO901
BLEU923-HIS933
CILE740-SER767
CVAL824-HIS829
CASN893-PRO901
CLEU923-HIS933
DVAL824-HIS829
DASN893-PRO901
DLEU923-HIS933
AILE740-SER767
AVAL824-HIS829
AASN893-PRO901
ALEU923-HIS933
BILE740-SER767

site_idSWS_FT_FI3
Number of Residues100
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DTYR768-PHE793
ATYR768-PHE793
BTYR768-PHE793
CTYR768-PHE793

site_idSWS_FT_FI4
Number of Residues692
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
DGLN794-ASN798
CGLN794-ASN798
CGLN851-MET862
CVAL961-PRO1119
DGLN851-MET862
DVAL961-PRO1119
AGLN794-ASN798
AGLN851-MET862
AVAL961-PRO1119
BGLN794-ASN798
BGLN851-MET862
BVAL961-PRO1119

site_idSWS_FT_FI5
Number of Residues96
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DTYR799-PHE823
ATYR799-PHE823
BTYR799-PHE823
CTYR799-PHE823

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DLEU830-LEU850
ALEU830-LEU850
BLEU830-LEU850
CLEU830-LEU850

site_idSWS_FT_FI7
Number of Residues116
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DLEU863-LEU892
ALEU863-LEU892
BLEU863-LEU892
CLEU863-LEU892

site_idSWS_FT_FI8
Number of Residues80
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DLEU902-PHE922
ALEU902-PHE922
BLEU902-PHE922
CLEU902-PHE922

site_idSWS_FT_FI9
Number of Residues104
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:31866091, ECO:0007744|PDB:6PQO
ChainResidueDetails
DPRO934-ALA960
APRO934-ALA960
BPRO934-ALA960
CPRO934-ALA960

site_idSWS_FT_FI10
Number of Residues8
DetailsBINDING: covalent => ECO:0000250|UniProtKB:Q8BLA8
ChainResidueDetails
DCYS414
DCYS421
ACYS414
ACYS421
BCYS414
BCYS421
CCYS414
CCYS421

site_idSWS_FT_FI11
Number of Residues4
DetailsBINDING: covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698
ChainResidueDetails
DCYS621
ACYS621
BCYS621
CCYS621

site_idSWS_FT_FI12
Number of Residues8
DetailsBINDING: covalent => ECO:0000305|PubMed:17164327
ChainResidueDetails
DCYS641
DLYS710
ACYS641
ALYS710
BCYS641
BLYS710
CCYS641
CLYS710

site_idSWS_FT_FI13
Number of Residues4
DetailsBINDING: covalent => ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698
ChainResidueDetails
DCYS665
ACYS665
BCYS665
CCYS665

site_idSWS_FT_FI14
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:32641835, ECO:0007744|PDB:6V9V
ChainResidueDetails
DGLU788
BGLN791
BASN805
BGLU808
CGLU788
CGLN791
CASN805
CGLU808
DGLN791
DASN805
DGLU808
AGLU788
AGLN791
AASN805
AGLU808
BGLU788

site_idSWS_FT_FI15
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:25855297
ChainResidueDetails
DLYS1046
ALYS1046
BLYS1046
CLYS1046

site_idSWS_FT_FI16
Number of Residues4
DetailsSITE: Required for C-621 reactivity => ECO:0000269|PubMed:27241698
ChainResidueDetails
DLYS620
ALYS620
BLYS620
CLYS620

site_idSWS_FT_FI17
Number of Residues4
DetailsSITE: Essential for electrophile activation. Sensor for electrophilic agents => ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835
ChainResidueDetails
DCYS621
ACYS621
BCYS621
CCYS621

site_idSWS_FT_FI18
Number of Residues4
DetailsSITE: Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178
ChainResidueDetails
DPRO622
APRO622
BPRO622
CPRO622

site_idSWS_FT_FI19
Number of Residues8
DetailsSITE: Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178
ChainResidueDetails
DMET634
DTHR646
AMET634
ATHR646
BMET634
BTHR646
CMET634
CTHR646

site_idSWS_FT_FI20
Number of Residues4
DetailsSITE: Important for electrophile activation => ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835
ChainResidueDetails
DCYS665
ACYS665
BCYS665
CCYS665

site_idSWS_FT_FI21
Number of Residues4
DetailsSITE: Crucial for calcium permeation => ECO:0000250|UniProtKB:Q6RI86
ChainResidueDetails
DASP915
AASP915
BASP915
CASP915

site_idSWS_FT_FI22
Number of Residues4
DetailsMOD_RES: 4-hydroxyproline; by EGLN1; transient; in normoxia and hyperoxia => ECO:0000269|PubMed:21873995
ChainResidueDetails
DPRO394
APRO394
BPRO394
CPRO394

site_idSWS_FT_FI23
Number of Residues8
DetailsMOD_RES: Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995
ChainResidueDetails
DCYS633
DCYS856
ACYS633
ACYS856
BCYS633
BCYS856
CCYS633
CCYS856

site_idSWS_FT_FI24
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN747
DASN753
AASN747
AASN753
BASN747
BASN753
CASN747
CASN753

225158

數據於2024-09-18公開中

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