3J9J
Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 560 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 |
| Chain | Residue | Details |
| A | ILE53-TYR73 | |
| B | GLU156-THR176 | |
| B | MET192-ILE219 | |
| B | VAL255-VAL283 | |
| C | ILE53-TYR73 | |
| C | TYR92-LEU117 | |
| C | TYR131-PHE151 | |
| C | GLU156-THR176 | |
| C | MET192-ILE219 | |
| C | VAL255-VAL283 | |
| D | ILE53-TYR73 | |
| A | TYR92-LEU117 | |
| D | TYR92-LEU117 | |
| D | TYR131-PHE151 | |
| D | GLU156-THR176 | |
| D | MET192-ILE219 | |
| D | VAL255-VAL283 | |
| A | TYR131-PHE151 | |
| A | GLU156-THR176 | |
| A | MET192-ILE219 | |
| A | VAL255-VAL283 | |
| B | ILE53-TYR73 | |
| B | TYR92-LEU117 | |
| B | TYR131-PHE151 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 184 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 |
| Chain | Residue | Details |
| A | TYR74-ASP91 | |
| D | TYR74-ASP91 | |
| D | SER152-LYS155 | |
| D | GLU220-PHE246 | |
| A | SER152-LYS155 | |
| A | GLU220-PHE246 | |
| B | TYR74-ASP91 | |
| B | SER152-LYS155 | |
| B | GLU220-PHE246 | |
| C | TYR74-ASP91 | |
| C | SER152-LYS155 | |
| C | GLU220-PHE246 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 |
| Chain | Residue | Details |
| A | GLN118-SER130 | |
| A | ARG177-LYS191 | |
| B | GLN118-SER130 | |
| B | ARG177-LYS191 | |
| C | GLN118-SER130 | |
| C | ARG177-LYS191 | |
| D | GLN118-SER130 | |
| D | ARG177-LYS191 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 |
| Chain | Residue | Details |
| A | TYR224-PHE246 | |
| B | TYR224-PHE246 | |
| C | TYR224-PHE246 | |
| D | TYR224-PHE246 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2PNN |
| Chain | Residue | Details |
| A | ARG-265 | |
| D | ARG-265 | |
| D | LYS-225 | |
| D | GLU-170 | |
| A | LYS-225 | |
| A | GLU-170 | |
| B | ARG-265 | |
| B | LYS-225 | |
| B | GLU-170 | |
| C | ARG-265 | |
| C | LYS-225 | |
| C | GLU-170 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2NYJ, ECO:0007744|PDB:2PNN |
| Chain | Residue | Details |
| A | LYS-220 | |
| D | LYS-220 | |
| D | ASN-216 | |
| D | TYR-181 | |
| A | ASN-216 | |
| A | TYR-181 | |
| B | LYS-220 | |
| B | ASN-216 | |
| B | TYR-181 | |
| C | LYS-220 | |
| C | ASN-216 | |
| C | TYR-181 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX |
| Chain | Residue | Details |
| A | TYR131 | |
| D | TYR131 | |
| D | THR170 | |
| D | ARG177 | |
| A | THR170 | |
| A | ARG177 | |
| B | TYR131 | |
| B | THR170 | |
| B | ARG177 | |
| C | TYR131 | |
| C | THR170 | |
| C | ARG177 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
| Chain | Residue | Details |
| A | ASP243 | |
| B | ASP243 | |
| C | ASP243 | |
| D | ASP243 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:15471852 |
| Chain | Residue | Details |
| A | SER-264 | |
| B | SER-264 | |
| C | SER-264 | |
| D | SER-264 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 |
| Chain | Residue | Details |
| A | THR-236 | |
| A | THR-10 | |
| B | THR-236 | |
| B | THR-10 | |
| C | THR-236 | |
| C | THR-10 | |
| D | THR-236 | |
| D | THR-10 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 |
| Chain | Residue | Details |
| A | SER122 | |
| B | SER122 | |
| C | SER122 | |
| D | SER122 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14630912 |
| Chain | Residue | Details |
| A | THR301 | |
| B | THR301 | |
| C | THR301 | |
| D | THR301 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 |
| Chain | Residue | Details |
| A | TYR224 | |
| B | TYR224 | |
| C | TYR224 | |
| D | TYR224 |
