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3J8H

Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003151biological_processoutflow tract morphogenesis
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008144molecular_functionobsolete drug binding
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014802cellular_componentterminal cisterna
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0016853molecular_functionisomerase activity
B0033017cellular_componentsarcoplasmic reticulum membrane
B0043231cellular_componentintracellular membrane-bounded organelle
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0098562cellular_componentcytoplasmic side of membrane
B1990425cellular_componentryanodine receptor complex
C0000166molecular_functionnucleotide binding
C0003151biological_processoutflow tract morphogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008144molecular_functionobsolete drug binding
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014802cellular_componentterminal cisterna
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0016853molecular_functionisomerase activity
D0033017cellular_componentsarcoplasmic reticulum membrane
D0043231cellular_componentintracellular membrane-bounded organelle
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0098562cellular_componentcytoplasmic side of membrane
D1990425cellular_componentryanodine receptor complex
E0000166molecular_functionnucleotide binding
E0003151biological_processoutflow tract morphogenesis
E0005216molecular_functionmonoatomic ion channel activity
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005245molecular_functionvoltage-gated calcium channel activity
E0005262molecular_functioncalcium channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005516molecular_functioncalmodulin binding
E0005524molecular_functionATP binding
E0005790cellular_componentsmooth endoplasmic reticulum
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006874biological_processintracellular calcium ion homeostasis
E0006936biological_processmuscle contraction
E0006941biological_processstriated muscle contraction
E0008144molecular_functionobsolete drug binding
E0014802cellular_componentterminal cisterna
E0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0015278molecular_functionintracellularly gated calcium channel activity
E0015643molecular_functiontoxic substance binding
E0016020cellular_componentmembrane
E0016529cellular_componentsarcoplasmic reticulum
E0019722biological_processcalcium-mediated signaling
E0030018cellular_componentZ disc
E0031090cellular_componentorganelle membrane
E0033017cellular_componentsarcoplasmic reticulum membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034704cellular_componentcalcium channel complex
E0035381molecular_functionATP-gated ion channel activity
E0042383cellular_componentsarcolemma
E0042802molecular_functionidentical protein binding
E0043588biological_processskin development
E0043931biological_processossification involved in bone maturation
E0044325molecular_functiontransmembrane transporter binding
E0046872molecular_functionmetal ion binding
E0048741biological_processskeletal muscle fiber development
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051289biological_processprotein homotetramerization
E0055085biological_processtransmembrane transport
E0070588biological_processcalcium ion transmembrane transport
E0071277biological_processcellular response to calcium ion
E0071313biological_processcellular response to caffeine
E0097718molecular_functiondisordered domain specific binding
E1990425cellular_componentryanodine receptor complex
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0008144molecular_functionobsolete drug binding
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0014802cellular_componentterminal cisterna
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0016853molecular_functionisomerase activity
F0033017cellular_componentsarcoplasmic reticulum membrane
F0043231cellular_componentintracellular membrane-bounded organelle
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0098562cellular_componentcytoplasmic side of membrane
F1990425cellular_componentryanodine receptor complex
G0000166molecular_functionnucleotide binding
G0003151biological_processoutflow tract morphogenesis
G0005216molecular_functionmonoatomic ion channel activity
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005262molecular_functioncalcium channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005790cellular_componentsmooth endoplasmic reticulum
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006874biological_processintracellular calcium ion homeostasis
G0006936biological_processmuscle contraction
G0006941biological_processstriated muscle contraction
G0008144molecular_functionobsolete drug binding
G0014802cellular_componentterminal cisterna
G0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0015278molecular_functionintracellularly gated calcium channel activity
G0015643molecular_functiontoxic substance binding
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0019722biological_processcalcium-mediated signaling
G0030018cellular_componentZ disc
G0031090cellular_componentorganelle membrane
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034704cellular_componentcalcium channel complex
G0035381molecular_functionATP-gated ion channel activity
G0042383cellular_componentsarcolemma
G0042802molecular_functionidentical protein binding
G0043588biological_processskin development
G0043931biological_processossification involved in bone maturation
G0044325molecular_functiontransmembrane transporter binding
G0046872molecular_functionmetal ion binding
G0048741biological_processskeletal muscle fiber development
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051289biological_processprotein homotetramerization
G0055085biological_processtransmembrane transport
G0070588biological_processcalcium ion transmembrane transport
G0071277biological_processcellular response to calcium ion
G0071313biological_processcellular response to caffeine
G0097718molecular_functiondisordered domain specific binding
G1990425cellular_componentryanodine receptor complex
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0008144molecular_functionobsolete drug binding
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0014802cellular_componentterminal cisterna
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0033017cellular_componentsarcoplasmic reticulum membrane
H0043231cellular_componentintracellular membrane-bounded organelle
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0098562cellular_componentcytoplasmic side of membrane
H1990425cellular_componentryanodine receptor complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
BLYS52
EASN4662-LYS4779
ELYS4821-LYS4835
EGLY4941-SER5037
GMET1-ILE4996
GASN4662-LYS4779
GLYS4821-LYS4835
GGLY4941-SER5037
DLYS52
FLYS52
HLYS52
CMET1-ILE4996
CASN4662-LYS4779
CLYS4821-LYS4835
CGLY4941-SER5037
EMET1-ILE4996

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4559-PHE4579
CPHE4559-PHE4579
EPHE4559-PHE4579
GPHE4559-PHE4579

site_idSWS_FT_FI3
Number of Residues408
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
ATYR4580-GLU4640
EHIS4803
EASN4857-MET4879
EGLU4900-THR4919
GTYR4580-GLU4640
GHIS4803
GASN4857-MET4879
GGLU4900-THR4919
AHIS4803
AASN4857-MET4879
AGLU4900-THR4919
CTYR4580-GLU4640
CHIS4803
CASN4857-MET4879
CGLU4900-THR4919
ETYR4580-GLU4640

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APRO4641-TYR4661
CPRO4641-TYR4661
EPRO4641-TYR4661
GPRO4641-TYR4661

site_idSWS_FT_FI5
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4780-GLY4802
CPHE4780-GLY4802
EPHE4780-GLY4802
GPHE4780-GLY4802

site_idSWS_FT_FI6
Number of Residues64
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
ATYR4804-VAL4820
CTYR4804-VAL4820
ETYR4804-VAL4820
GTYR4804-VAL4820

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AGLN4836-PHE4856
CGLN4836-PHE4856
EGLN4836-PHE4856
GGLN4836-PHE4856

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AMET4880-ASP4899
CMET4880-ASP4899
EMET4880-ASP4899
GMET4880-ASP4899

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4920-PHE4940
CPHE4920-PHE4940
EPHE4920-PHE4940
GPHE4920-PHE4940

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN
ChainResidueDetails
AGLU3893
GGLU3893
GGLU3967
GTHR5001
AGLU3967
ATHR5001
CGLU3893
CGLU3967
CTHR5001
EGLU3893
EGLU3967
ETHR5001

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU
ChainResidueDetails
ALYS4211
GLYS4211
GMET4954
GTHR4979
AMET4954
ATHR4979
CLYS4211
CMET4954
CTHR4979
ELYS4211
EMET4954
ETHR4979

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN
ChainResidueDetails
ATRP4716
CTRP4716
ETRP4716
GTRP4716

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ASER1338
GSER1338
GSER2345
GSER4470
ASER2345
ASER4470
CSER1338
CSER2345
CSER4470
ESER1338
ESER2345
ESER4470

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342
ChainResidueDetails
ASER2843
CSER2843
ESER2843
GSER2843

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
AGLY4073
CGLY4073
EGLY4073
GGLY4073

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ATHR4466
CTHR4466
ETHR4466
GTHR4466

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ATYR4863
CTYR4863
ETYR4863
GTYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ASER4866
CSER4866
ESER4866
GSER4866

218853

PDB entries from 2024-04-24

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