3J8H

Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003151	biological_process	outflow tract morphogenesis
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006936	biological_process	muscle contraction
A	0006941	biological_process	striated muscle contraction
A	0008144	molecular_function	obsolete drug binding
A	0014802	cellular_component	terminal cisterna
A	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0015278	molecular_function	intracellularly gated calcium channel activity
A	0015643	molecular_function	toxic substance binding
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019722	biological_process	calcium-mediated signaling
A	0030018	cellular_component	Z disc
A	0031090	cellular_component	organelle membrane
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034704	cellular_component	calcium channel complex
A	0035381	molecular_function	ATP-gated ion channel activity
A	0042383	cellular_component	sarcolemma
A	0042802	molecular_function	identical protein binding
A	0043588	biological_process	skin development
A	0043931	biological_process	ossification involved in bone maturation
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051289	biological_process	protein homotetramerization
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071277	biological_process	cellular response to calcium ion
A	0071313	biological_process	cellular response to caffeine
A	0097718	molecular_function	disordered domain specific binding
A	1990425	cellular_component	ryanodine receptor complex
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008144	molecular_function	obsolete drug binding
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0014802	cellular_component	terminal cisterna
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016853	molecular_function	isomerase activity
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0098562	cellular_component	cytoplasmic side of membrane
B	1990425	cellular_component	ryanodine receptor complex
C	0000166	molecular_function	nucleotide binding
C	0003151	biological_process	outflow tract morphogenesis
C	0005216	molecular_function	monoatomic ion channel activity
C	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
C	0005245	molecular_function	voltage-gated calcium channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0006936	biological_process	muscle contraction
C	0006941	biological_process	striated muscle contraction
C	0008144	molecular_function	obsolete drug binding
C	0014802	cellular_component	terminal cisterna
C	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0015278	molecular_function	intracellularly gated calcium channel activity
C	0015643	molecular_function	toxic substance binding
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0019722	biological_process	calcium-mediated signaling
C	0030018	cellular_component	Z disc
C	0031090	cellular_component	organelle membrane
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034704	cellular_component	calcium channel complex
C	0035381	molecular_function	ATP-gated ion channel activity
C	0042383	cellular_component	sarcolemma
C	0042802	molecular_function	identical protein binding
C	0043588	biological_process	skin development
C	0043931	biological_process	ossification involved in bone maturation
C	0044325	molecular_function	transmembrane transporter binding
C	0046872	molecular_function	metal ion binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0051289	biological_process	protein homotetramerization
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071277	biological_process	cellular response to calcium ion
C	0071313	biological_process	cellular response to caffeine
C	0097718	molecular_function	disordered domain specific binding
C	1990425	cellular_component	ryanodine receptor complex
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008144	molecular_function	obsolete drug binding
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0014802	cellular_component	terminal cisterna
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0016853	molecular_function	isomerase activity
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
D	0098562	cellular_component	cytoplasmic side of membrane
D	1990425	cellular_component	ryanodine receptor complex
E	0000166	molecular_function	nucleotide binding
E	0003151	biological_process	outflow tract morphogenesis
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005262	molecular_function	calcium channel activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005524	molecular_function	ATP binding
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0006936	biological_process	muscle contraction
E	0006941	biological_process	striated muscle contraction
E	0008144	molecular_function	obsolete drug binding
E	0014802	cellular_component	terminal cisterna
E	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0015278	molecular_function	intracellularly gated calcium channel activity
E	0015643	molecular_function	toxic substance binding
E	0016020	cellular_component	membrane
E	0016529	cellular_component	sarcoplasmic reticulum
E	0019722	biological_process	calcium-mediated signaling
E	0030018	cellular_component	Z disc
E	0031090	cellular_component	organelle membrane
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034704	cellular_component	calcium channel complex
E	0035381	molecular_function	ATP-gated ion channel activity
E	0042383	cellular_component	sarcolemma
E	0042802	molecular_function	identical protein binding
E	0043588	biological_process	skin development
E	0043931	biological_process	ossification involved in bone maturation
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0051289	biological_process	protein homotetramerization
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
E	0071277	biological_process	cellular response to calcium ion
E	0071313	biological_process	cellular response to caffeine
E	0097718	molecular_function	disordered domain specific binding
E	1990425	cellular_component	ryanodine receptor complex
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008144	molecular_function	obsolete drug binding
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0014802	cellular_component	terminal cisterna
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0016853	molecular_function	isomerase activity
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
F	0098562	cellular_component	cytoplasmic side of membrane
F	1990425	cellular_component	ryanodine receptor complex
G	0000166	molecular_function	nucleotide binding
G	0003151	biological_process	outflow tract morphogenesis
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005790	cellular_component	smooth endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0006936	biological_process	muscle contraction
G	0006941	biological_process	striated muscle contraction
G	0008144	molecular_function	obsolete drug binding
G	0014802	cellular_component	terminal cisterna
G	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0015278	molecular_function	intracellularly gated calcium channel activity
G	0015643	molecular_function	toxic substance binding
G	0016020	cellular_component	membrane
G	0016529	cellular_component	sarcoplasmic reticulum
G	0019722	biological_process	calcium-mediated signaling
G	0030018	cellular_component	Z disc
G	0031090	cellular_component	organelle membrane
G	0033017	cellular_component	sarcoplasmic reticulum membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034704	cellular_component	calcium channel complex
G	0035381	molecular_function	ATP-gated ion channel activity
G	0042383	cellular_component	sarcolemma
G	0042802	molecular_function	identical protein binding
G	0043588	biological_process	skin development
G	0043931	biological_process	ossification involved in bone maturation
G	0044325	molecular_function	transmembrane transporter binding
G	0046872	molecular_function	metal ion binding
G	0048741	biological_process	skeletal muscle fiber development
G	0051209	biological_process	release of sequestered calcium ion into cytosol
G	0051289	biological_process	protein homotetramerization
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
G	0071277	biological_process	cellular response to calcium ion
G	0071313	biological_process	cellular response to caffeine
G	0097718	molecular_function	disordered domain specific binding
G	1990425	cellular_component	ryanodine receptor complex
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008144	molecular_function	obsolete drug binding
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0014802	cellular_component	terminal cisterna
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0098562	cellular_component	cytoplasmic side of membrane
H	1990425	cellular_component	ryanodine receptor complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA and PKG","evidences":[{"source":"PubMed","id":"8380342","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P26883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---