3J8B

Model of the human eIF3 PCI-MPN octamer docked into the 43S-HCV IRES EM map

Replaces:  3J7J

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
C	0006413	biological_process	translational initiation
C	0031369	molecular_function	translation initiation factor binding
E	0003743	molecular_function	translation initiation factor activity
E	0005737	cellular_component	cytoplasm
E	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
F	0003743	molecular_function	translation initiation factor activity
F	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
F	0006413	biological_process	translational initiation
F	0008233	molecular_function	peptidase activity
F	0008237	molecular_function	metallopeptidase activity
F	0031369	molecular_function	translation initiation factor binding
H	0003743	molecular_function	translation initiation factor activity
H	0005737	cellular_component	cytoplasm
H	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
H	0008233	molecular_function	peptidase activity
H	0008237	molecular_function	metallopeptidase activity
K	0003743	molecular_function	translation initiation factor activity
K	0005737	cellular_component	cytoplasm
K	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
K	0006446	biological_process	regulation of translational initiation
K	0043022	molecular_function	ribosome binding
L	0001650	cellular_component	fibrillar center
L	0001732	biological_process	formation of cytoplasmic translation initiation complex
L	0002183	biological_process	cytoplasmic translational initiation
L	0003723	molecular_function	RNA binding
L	0003743	molecular_function	translation initiation factor activity
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
L	0016020	cellular_component	membrane
L	0016282	cellular_component	eukaryotic 43S preinitiation complex
L	0032991	cellular_component	protein-containing complex
L	0033290	cellular_component	eukaryotic 48S preinitiation complex
L	0045202	cellular_component	synapse
L	0075525	biological_process	viral translational termination-reinitiation
M	0001732	biological_process	formation of cytoplasmic translation initiation complex
M	0002183	biological_process	cytoplasmic translational initiation
M	0003743	molecular_function	translation initiation factor activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
M	0016282	cellular_component	eukaryotic 43S preinitiation complex
M	0031369	molecular_function	translation initiation factor binding
M	0032991	cellular_component	protein-containing complex
M	0033290	cellular_component	eukaryotic 48S preinitiation complex
M	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
M	SER2

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
M	SER152

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
M	LYS254

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