3J5S

EttA binds to ribosome exit site and regulates translation by restricting ribosome and tRNA dynamics

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0003747	molecular_function	translation release factor activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006412	biological_process	translation
D	0006415	biological_process	translational termination
D	0006417	biological_process	regulation of translation
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019843	molecular_function	rRNA binding
D	0043022	molecular_function	ribosome binding
D	0045900	biological_process	negative regulation of translational elongation
F	0000027	biological_process	ribosomal large subunit assembly
F	0000049	molecular_function	tRNA binding
F	0002181	biological_process	cytoplasmic translation
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0006417	biological_process	regulation of translation
F	0015934	cellular_component	large ribosomal subunit
F	0019843	molecular_function	rRNA binding
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	0045947	biological_process	negative regulation of translational initiation
F	1990904	cellular_component	ribonucleoprotein complex
G	0000027	biological_process	ribosomal large subunit assembly
G	0000049	molecular_function	tRNA binding
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0008097	molecular_function	5S rRNA binding
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	1990904	cellular_component	ribonucleoprotein complex
H	0000027	biological_process	ribosomal large subunit assembly
H	0000049	molecular_function	tRNA binding
H	0002181	biological_process	cytoplasmic translation
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	0046677	biological_process	response to antibiotic
H	1990904	cellular_component	ribonucleoprotein complex
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0006412	biological_process	translation
I	0015935	cellular_component	small ribosomal subunit

Functional Information from PROSITE/UniProt

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNkrtkPekLElkKFD

Chain	Residue	Details
H	TYR20-ASP39

---

site_id	PS01199
Number of Residues	19
Details	RIBOSOMAL_L1 Ribosomal protein L1 signature. MrvVgq.LGqvLGPRGlMPN

Chain	Residue	Details
F	MET121-ASN139

---

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERRRVALCRLL

Chain	Residue	Details
D	LEU163-LEU177

---

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. SeLlakFVnilmvdGKKstaesIVysA

Chain	Residue	Details
I	SER19-ALA45

---

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LaaISGQkpLiTkARkS

Chain	Residue	Details
G	LEU56-SER72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	253
Details	Domain: {"description":"ABC transporter 1","evidences":[{"source":"HAMAP-Rule","id":"MF_00847","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	226
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"HAMAP-Rule","id":"MF_00847","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Region: {"description":"Arm","evidences":[{"source":"HAMAP-Rule","id":"MF_00847","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24389465","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Region: {"description":"PtIM","evidences":[{"source":"HAMAP-Rule","id":"MF_00847","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24389465","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00847","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---