3J0A
Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0002376 | biological_process | immune system process |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005149 | molecular_function | interleukin-1 receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0032757 | biological_process | positive regulation of interleukin-8 production |
| A | 0034146 | biological_process | toll-like receptor 5 signaling pathway |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0038187 | molecular_function | pattern recognition receptor activity |
| A | 0045087 | biological_process | innate immune response |
| A | 0071260 | biological_process | cellular response to mechanical stimulus |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0002376 | biological_process | immune system process |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005149 | molecular_function | interleukin-1 receptor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006955 | biological_process | immune response |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0032757 | biological_process | positive regulation of interleukin-8 production |
| B | 0034146 | biological_process | toll-like receptor 5 signaling pathway |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0038187 | molecular_function | pattern recognition receptor activity |
| B | 0045087 | biological_process | innate immune response |
| B | 0071260 | biological_process | cellular response to mechanical stimulus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 28 |
| Details | Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 24 |
| Details | Repeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 13","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"LRR 14","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"LRR 16","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"LRR 17","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 18","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 19","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 20","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"LRR 21","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"LRR 22","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 145 |
| Details | Domain: {"description":"TIR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17157808","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKD/PRKD1","evidences":[{"source":"PubMed","id":"17442957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 14 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22173220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
