3J09

High resolution helical reconstruction of the bacterial p-type ATPase copper transporter CopA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005507	molecular_function	copper ion binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0006825	biological_process	copper ion transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0035434	biological_process	copper ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0043682	molecular_function	P-type divalent copper transporter activity
A	0046872	molecular_function	metal ion binding
A	0055070	biological_process	copper ion homeostasis
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0140581	molecular_function	P-type monovalent copper transporter activity
B	0000166	molecular_function	nucleotide binding
B	0005215	molecular_function	transporter activity
B	0005507	molecular_function	copper ion binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006812	biological_process	monoatomic cation transport
B	0006825	biological_process	copper ion transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0035434	biological_process	copper ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0043682	molecular_function	P-type divalent copper transporter activity
B	0046872	molecular_function	metal ion binding
B	0055070	biological_process	copper ion homeostasis
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0140581	molecular_function	P-type monovalent copper transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP424-THR430

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site_id	PS01199
Number of Residues	19
Details	RIBOSOMAL_L1 Ribosomal protein L1 signature. GvgAaf.LAsvLSTAGvLPR

Chain	Residue	Details
A	GLY165-ARG183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	314
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU102-PRO122
B	LEU129-SER149
B	VAL160-VAL180
B	PHE187-LEU204
B	ALA340-ILE360
B	LEU365-GLY385
B	ILE681-VAL701
B	GLU705-LEU725
A	LEU129-SER149
A	VAL160-VAL180
A	PHE187-LEU204
A	ALA340-ILE360
A	LEU365-GLY385
A	ILE681-VAL701
A	GLU705-LEU725
B	LEU102-PRO122

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	TYR123-GLN128
A	LEU181-SER186
A	ALA361-PRO364
A	PHE702-PRO704
B	TYR123-GLN128
B	LEU181-SER186
B	ALA361-PRO364
B	PHE702-PRO704

---

site_id	SWS_FT_FI3
Number of Residues	874
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	ALA150-ASP159
A	GLU205-VAL339
A	LEU386-LEU680
B	ALA150-ASP159
B	GLU205-VAL339
B	LEU386-LEU680

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250

Chain	Residue	Details
A	ASP424
B	ASP424

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00280

Chain	Residue	Details
A	CYS27
A	CYS30
B	CYS27
B	CYS30

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLU457
A	GLY490
B	GLU457
B	GLY490

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	ASP618
A	ASP622
B	ASP618
B	ASP622

---