3IXP

Crystal structure of the ecdysone receptor bound to BYI08346

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0004879	molecular_function	nuclear receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0030522	biological_process	intracellular receptor signaling pathway
A	0043401	biological_process	steroid hormone receptor signaling pathway
D	0003677	molecular_function	DNA binding
D	0004879	molecular_function	nuclear receptor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0035076	biological_process	ecdysone receptor signaling pathway
D	0035100	molecular_function	ecdysone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE EPH A 900

Chain	Residue
A	LEU230
A	ALA339
A	GLY340
A	ILE344
A	SER431
A	LEU435
A	PHE438
A	LEU440
A	HOH993
A	VAL238
A	PRO239
A	PHE242
A	LEU249
A	CYS250
A	GLY328
A	LEU331
A	GLN338

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 834 D 800

Chain	Residue
D	THR343
D	MET380
D	MET381
D	VAL384
D	TYR408
D	MET413
D	VAL416
D	LEU420
D	GLN503
D	ASN504
D	MET507
D	LEU522

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