3IW1
Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with androstenedione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051701 | biological_process | biological process involved in interaction with host |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ASD A 1223 |
| Chain | Residue |
| A | VAL111 |
| A | MET200 |
| A | GLY202 |
| A | SER217 |
| A | VAL297 |
| A | HOH561 |
| A | HOH579 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM A 434 |
| Chain | Residue |
| A | ARG128 |
| A | PHE135 |
| A | MET264 |
| A | ALA268 |
| A | GLY269 |
| A | THR272 |
| A | THR273 |
| A | PRO312 |
| A | PHE316 |
| A | ARG318 |
| A | GLY368 |
| A | PHE369 |
| A | GLY370 |
| A | GLY371 |
| A | HIS375 |
| A | CYS377 |
| A | ILE378 |
| A | GLY379 |
| A | HOH459 |
| A | HOH466 |
| A | HOH531 |
| A | HOH601 |
| A | LEU117 |
| A | HIS124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19846552, ECO:0007744|PDB:3IW1 |
| Chain | Residue | Details |
| A | GLY202 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20545858, ECO:0007744|PDB:2X5L, ECO:0007744|PDB:2X5W, ECO:0007744|PDB:2XC3, ECO:0007744|PDB:2XN8, ECO:0007744|PDB:3IVY, ECO:0007744|PDB:3IW0, ECO:0007744|PDB:3IW1, ECO:0007744|PDB:3IW2 |
| Chain | Residue | Details |
| A | CYS377 |
