3IVY

Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125, p212121 crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006707	biological_process	cholesterol catabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016042	biological_process	lipid catabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
A	0046872	molecular_function	metal ion binding
A	0051701	biological_process	biological process involved in interaction with host

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM A 501

Chain	Residue
A	LEU117
A	PHE316
A	ARG318
A	GLY368
A	PHE369
A	GLY370
A	HIS375
A	CYS377
A	ILE378
A	GLY379
A	HOH610
A	HIS124
A	HOH717
A	HOH721
A	HOH786
A	HOH943
A	ARG128
A	MET264
A	ALA268
A	GLY269
A	THR272
A	THR273
A	SER276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:19846552, ECO:0007744|PDB:3IW1

Chain	Residue	Details
A	GLY202

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:20545858, ECO:0007744|PDB:2X5L, ECO:0007744|PDB:2X5W, ECO:0007744|PDB:2XC3, ECO:0007744|PDB:2XN8, ECO:0007744|PDB:3IVY, ECO:0007744|PDB:3IW0, ECO:0007744|PDB:3IW1, ECO:0007744|PDB:3IW2

Chain	Residue	Details
A	CYS377

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	THR272
A	GLU271

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