3IV2

Crystal structure of mature apo-Cathepsin L C25A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG

Chain	Residue	Details
A	MET161-GLY171

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site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM

Chain	Residue	Details
A	TYR182-MET201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:9468501

Chain	Residue	Details
A	ALA25
B	ALA25

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE:

Chain	Residue	Details
A	HIS163
A	ASN187
B	HIS163
B	ASN187

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site_id	SWS_FT_FI3
Number of Residues	22
Details	BINDING: BINDING => ECO:0000269|PubMed:37990007, ECO:0007744|PDB:8HFV

Chain	Residue	Details
A	GLU9
A	ASP160
A	ASP162
B	GLU9
B	GLU50
B	ASP71
B	GLU86
B	GLU92
B	GLU96
B	ASP114
B	ASP137
A	GLU50
B	HIS140
B	ASP160
B	ASP162
A	ASP71
A	GLU86
A	GLU92
A	GLU96
A	ASP114
A	ASP137
A	HIS140

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN108
B	ASN108

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