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3ISS

Crystal structure of enolpyruvyl-UDP-GlcNAc synthase (MurA):UDP-N-acetylmuramic acid:phosphite from Escherichia coli

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008360biological_processregulation of cell shape
A0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
A0009252biological_processpeptidoglycan biosynthetic process
A0016740molecular_functiontransferase activity
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
A0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
A0051301biological_processcell division
A0071555biological_processcell wall organization
B0003824molecular_functioncatalytic activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008360biological_processregulation of cell shape
B0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
B0009252biological_processpeptidoglycan biosynthetic process
B0016740molecular_functiontransferase activity
B0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
B0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
B0051301biological_processcell division
B0071555biological_processcell wall organization
C0003824molecular_functioncatalytic activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0008360biological_processregulation of cell shape
C0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
C0009252biological_processpeptidoglycan biosynthetic process
C0016740molecular_functiontransferase activity
C0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
C0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
C0051301biological_processcell division
C0071555biological_processcell wall organization
D0003824molecular_functioncatalytic activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008360biological_processregulation of cell shape
D0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
D0009252biological_processpeptidoglycan biosynthetic process
D0016740molecular_functiontransferase activity
D0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
D0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
D0051301biological_processcell division
D0071555biological_processcell wall organization
E0003824molecular_functioncatalytic activity
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0008360biological_processregulation of cell shape
E0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
E0009252biological_processpeptidoglycan biosynthetic process
E0016740molecular_functiontransferase activity
E0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
E0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
E0051301biological_processcell division
E0071555biological_processcell wall organization
F0003824molecular_functioncatalytic activity
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0008360biological_processregulation of cell shape
F0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
F0009252biological_processpeptidoglycan biosynthetic process
F0016740molecular_functiontransferase activity
F0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
F0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
F0051301biological_processcell division
F0071555biological_processcell wall organization
G0003824molecular_functioncatalytic activity
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0008360biological_processregulation of cell shape
G0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
G0009252biological_processpeptidoglycan biosynthetic process
G0016740molecular_functiontransferase activity
G0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
G0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
G0051301biological_processcell division
G0071555biological_processcell wall organization
H0003824molecular_functioncatalytic activity
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0008360biological_processregulation of cell shape
H0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
H0009252biological_processpeptidoglycan biosynthetic process
H0016740molecular_functiontransferase activity
H0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
H0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
H0051301biological_processcell division
H0071555biological_processcell wall organization
I0003824molecular_functioncatalytic activity
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0008360biological_processregulation of cell shape
I0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
I0009252biological_processpeptidoglycan biosynthetic process
I0016740molecular_functiontransferase activity
I0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
I0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
I0051301biological_processcell division
I0071555biological_processcell wall organization
J0003824molecular_functioncatalytic activity
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0008360biological_processregulation of cell shape
J0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
J0009252biological_processpeptidoglycan biosynthetic process
J0016740molecular_functiontransferase activity
J0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
J0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
J0051301biological_processcell division
J0071555biological_processcell wall organization
K0003824molecular_functioncatalytic activity
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0008360biological_processregulation of cell shape
K0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
K0009252biological_processpeptidoglycan biosynthetic process
K0016740molecular_functiontransferase activity
K0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
K0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
K0051301biological_processcell division
K0071555biological_processcell wall organization
L0003824molecular_functioncatalytic activity
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0008360biological_processregulation of cell shape
L0008760molecular_functionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
L0009252biological_processpeptidoglycan biosynthetic process
L0016740molecular_functiontransferase activity
L0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
L0019277biological_processUDP-N-acetylgalactosamine biosynthetic process
L0051301biological_processcell division
L0071555biological_processcell wall organization
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO3 A 501
ChainResidue
AARG91
AARG397

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE EPU A 601
ChainResidue
ALEU124
ALYS160
AVAL161
ASER162
AVAL163
AGLY164
AASP305
AVAL327
APHE328
ALEU370
AHOH425
AHOH445
AHOH780
ALYS22
AASN23
AALA119
AARG120
APRO121
AVAL122
AASP123

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO3 B 502
ChainResidue
BARG91
BCYS115
BARG397

site_idAC4
Number of Residues23
DetailsBINDING SITE FOR RESIDUE EPU B 602
ChainResidue
BLYS22
BASN23
BALA92
BTRP95
BALA119
BARG120
BPRO121
BVAL122
BASP123
BLEU124
BHIS125
BLYS160
BSER162
BVAL163
BGLY164
BTHR304
BASP305
BVAL327
BPHE328
BLEU370
BARG371
BHOH441
BHOH650

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO3 C 502
ChainResidue
CARG91
CCYS115
CARG120
CARG397

site_idAC6
Number of Residues21
DetailsBINDING SITE FOR RESIDUE EPU C 603
ChainResidue
CLYS22
CASN23
CALA119
CARG120
CPRO121
CVAL122
CASP123
CLEU124
CLYS160
CSER162
CVAL163
CGLY164
CASP305
CVAL327
CPHE328
CLEU370
CHOH423
CHOH469
CHOH470
CHOH555
CHOH797

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO3 D 503
ChainResidue
DARG91
DCYS115
DARG120
DHOH663

site_idAC8
Number of Residues20
DetailsBINDING SITE FOR RESIDUE EPU D 604
ChainResidue
DLYS22
DASN23
DTRP95
DALA119
DARG120
DPRO121
DVAL122
DASP123
DLEU124
DHIS125
DLYS160
DSER162
DVAL163
DGLY164
DASP305
DVAL327
DPHE328
DLEU370
DHOH435
DHOH471

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO3 E 504
ChainResidue
ECYS115
EARG397

site_idBC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE EPU E 605
ChainResidue
ELYS22
EASN23
ETRP95
EALA119
EARG120
EPRO121
EVAL122
EASP123
ELEU124
ELYS160
ESER162
EVAL163
EGLY164
EASP305
EVAL327
ELEU370
EARG371
EHOH442
EHOH456

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO3 F 506
ChainResidue
FARG91
FARG397

site_idBC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE EPU F 606
ChainResidue
FLYS22
FASN23
FALA119
FARG120
FPRO121
FVAL122
FASP123
FLEU124
FHIS125
FLYS160
FSER162
FVAL163
FGLY164
FASP305
FVAL327
FPHE328
FLEU370
FHOH488
FHOH603

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO3 G 507
ChainResidue
GARG91
GCYS115
GARG397

site_idBC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE EPU G 607
ChainResidue
GLYS22
GASN23
GALA92
GTRP95
GALA119
GARG120
GPRO121
GVAL122
GASP123
GLEU124
GHIS125
GLYS160
GSER162
GVAL163
GGLY164
GASP305
GVAL327
GARG331
GLEU370

site_idBC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO3 H 508
ChainResidue
HARG91
HCYS115
HARG397

site_idBC7
Number of Residues18
DetailsBINDING SITE FOR RESIDUE EPU H 608
ChainResidue
HASN23
HALA119
HARG120
HPRO121
HVAL122
HASP123
HLEU124
HHIS125
HLYS160
HSER162
HVAL163
HGLY164
HASP305
HVAL327
HPHE328
HARG371
HHOH426
HHOH469

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO3 I 509
ChainResidue
IARG91
ICYS115
IARG397

site_idBC9
Number of Residues17
DetailsBINDING SITE FOR RESIDUE EPU I 609
ChainResidue
ILYS22
IASN23
IALA119
IARG120
IPRO121
IVAL122
IASP123
ILEU124
ILYS160
ISER162
IVAL163
IGLY164
IASP305
IVAL327
IPHE328
ILEU370
IHOH438

site_idCC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO3 J 510
ChainResidue
JMET90
JARG91
JCYS115
JARG397
JHOH764

site_idCC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE EPU J 610
ChainResidue
JLYS22
JASN23
JTRP95
JALA119
JARG120
JPRO121
JVAL122
JASP123
JLEU124
JHIS125
JLYS160
JSER162
JVAL163
JGLY164
JASP305
JVAL327
JPHE328
JLEU370
JARG371
JHOH443
JHOH673

site_idCC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO3 K 511
ChainResidue
KARG91
KCYS115
KARG397

site_idCC4
Number of Residues23
DetailsBINDING SITE FOR RESIDUE EPU K 611
ChainResidue
KLYS22
KASN23
KALA119
KARG120
KPRO121
KVAL122
KASP123
KLEU124
KHIS125
KLYS160
KSER162
KVAL163
KGLY164
KASP305
KVAL327
KPHE328
KLEU370
KHOH424
KHOH425
KHOH427
KHOH444
KHOH457
KHOH477

site_idCC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO3 L 512
ChainResidue
LARG91
LARG397

site_idCC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE EPU L 612
ChainResidue
LLYS22
LASN23
LALA119
LARG120
LPRO121
LVAL122
LASP123
LLEU124
LLYS160
LVAL161
LSER162
LVAL163
LGLY164
LASP305
LVAL327
LPHE328
LLEU370

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:20392080, ECO:0000269|PubMed:8994972, ECO:0000305|PubMed:22378791, ECO:0007744|PDB:1UAE, ECO:0007744|PDB:3KR6
ChainResidueDetails
ACYS115
JCYS115
KCYS115
LCYS115
BCYS115
CCYS115
DCYS115
ECYS115
FCYS115
GCYS115
HCYS115
ICYS115

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:20392080, ECO:0000305|PubMed:22378791, ECO:0007744|PDB:3KR6, ECO:0007744|PDB:3SWD
ChainResidueDetails
ALYS22
JLYS22
KLYS22
LLYS22
BLYS22
CLYS22
DLYS22
ELYS22
FLYS22
GLYS22
HLYS22
ILYS22

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:20392080, ECO:0007744|PDB:3KR6
ChainResidueDetails
AARG91
EVAL327
FARG91
FVAL327
GARG91
GVAL327
HARG91
HVAL327
IARG91
IVAL327
JARG91
AVAL327
JVAL327
KARG91
KVAL327
LARG91
LVAL327
BARG91
BVAL327
CARG91
CVAL327
DARG91
DVAL327
EARG91

site_idSWS_FT_FI4
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:20392080, ECO:0000269|PubMed:22378791, ECO:0007744|PDB:3KR6
ChainResidueDetails
AARG120
DARG120
DLYS160
DASP305
EARG120
ELYS160
EASP305
FARG120
FLYS160
FASP305
GARG120
ALYS160
GLYS160
GASP305
HARG120
HLYS160
HASP305
IARG120
ILYS160
IASP305
JARG120
JLYS160
AASP305
JASP305
KARG120
KLYS160
KASP305
LARG120
LLYS160
LASP305
BARG120
BLYS160
BASP305
CARG120
CLYS160
CASP305

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: 2-(S-cysteinyl)pyruvic acid O-phosphothioketal => ECO:0000305|PubMed:22378791
ChainResidueDetails
ACYS115
JCYS115
KCYS115
LCYS115
BCYS115
CCYS115
DCYS115
ECYS115
FCYS115
GCYS115
HCYS115
ICYS115

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
AASP305
AARG397
ACYS115
AASN23

site_idCSA10
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
JASP305
JARG397
JCYS115
JASN23

site_idCSA11
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
KASP305
KARG397
KCYS115
KASN23

site_idCSA12
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
LASP305
LARG397
LCYS115
LASN23

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
BASP305
BARG397
BCYS115
BASN23

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
CASP305
CARG397
CCYS115
CASN23

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
DASP305
DARG397
DCYS115
DASN23

site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
EASP305
EARG397
ECYS115
EASN23

site_idCSA6
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
FASP305
FARG397
FCYS115
FASN23

site_idCSA7
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
GASP305
GARG397
GCYS115
GASN23

site_idCSA8
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
HASP305
HARG397
HCYS115
HASN23

site_idCSA9
Number of Residues4
DetailsAnnotated By Reference To The Literature 1uae
ChainResidueDetails
IASP305
IARG397
ICYS115
IASN23

222926

PDB entries from 2024-07-24

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