3ISN

Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003676	molecular_function	nucleic acid binding
C	0003964	molecular_function	RNA-directed DNA polymerase activity
C	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
C	0006278	biological_process	RNA-templated DNA biosynthetic process
D	0003964	molecular_function	RNA-directed DNA polymerase activity
D	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDM C 561

Chain	Residue
C	MET184
C	ASP186
C	MET230
C	GLY231
C	LYS263
C	TRP266
C	HOH578
C	HOH631
C	HOH672

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial"}

Chain

Residue

Details

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