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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3IS5

Crystal structure of CDPK kinase domain from toxoplasma Gondii, TGME49_018720

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0004672	molecular_function	protein kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A 1

Chain	Residue
A	HOH106
A	MET210
A	GLU211
A	THR212
A	CYS213
A	GLU217
A	LEU267
A	ILE280
A	MG399
A	LEU141
A	GLY142
A	SER143
A	GLY144
A	VAL149
A	VAL162
A	LYS164
A	ILE194

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 397

Chain	Residue
A	GLU154
A	HOH457
B	GLU154

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 398

Chain	Residue
A	LYS164
A	MET210
A	ASP281
A	PHE282

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 399

Chain	Residue
A	ANP1
A	ASN265
A	ASP281

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 400

Chain	Residue
A	ARG221
A	TYR236
A	PHE268
A	ASP270
A	SER272
A	PRO273

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP B 1

Chain	Residue
B	LEU141
B	GLY142
B	SER143
B	GLY144
B	VAL162
B	LYS164
B	ILE194
B	MET210
B	GLU211
B	CYS213
B	GLU217
B	LEU267
B	ASP281
B	MG397
B	HOH402
B	HOH479

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 397

Chain	Residue
B	ANP1
B	ASN265
B	ASP281

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 398

Chain	Residue
B	MET210
B	ILE280
B	ASP281
B	PHE282
B	HOH479

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP C 1

Chain	Residue
C	LEU141
C	GLY142
C	SER143
C	VAL149
C	VAL162
C	ILE194
C	MET210
C	GLU211
C	CYS213
C	GLU217
C	LEU267
C	ASP281
C	MG398
C	HOH401
C	HOH488
C	HOH553

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 397

Chain	Residue
C	GLU154
C	GLU198
D	GLU154
D	GLU198

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 398

Chain	Residue
C	ANP1
C	ASN265
C	ASP281

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP D 1

Chain	Residue
D	LEU141
D	GLY142
D	SER143
D	GLY144
D	VAL162
D	ILE194
D	MET210
D	GLU211
D	THR212
D	CYS213
D	GLU217
D	LEU267
D	ASP281
D	MG399
D	HOH530
D	HOH564

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 397

Chain	Residue
D	ASP132
D	PHE137
D	THR165

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 398

Chain	Residue
D	LYS164
D	MET210
D	ASP281
D	PHE282

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 399

Chain	Residue
D	ANP1
D	ASN265
D	ASP281

site_id	BC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP E 1

Chain	Residue
E	LEU141
E	GLY142
E	GLY144
E	VAL149
E	VAL162
E	ILE194
E	MET210
E	GLU211
E	CYS213
E	GLU217
E	LEU267
E	ASP281
E	MG398
E	HOH399
E	HOH490
E	HOH539

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL E 397

Chain	Residue
E	ILE196
E	MET210
E	ASP281
E	PHE282

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 398

Chain	Residue
E	ANP1
E	ASN265
E	ASP281

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 1

Chain	Residue
E	GLU154
E	GLU198
E	HOH555
F	GLU154
F	GLU198
F	HOH556

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 397

Chain	Residue
F	ASN265
F	ASP281
F	HOH532
F	HOH533
F	HOH534
F	HOH535

site_id	CC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP F 398

Chain	Residue
F	LEU141
F	GLY142
F	SER143
F	GLY144
F	VAL162
F	ILE194
F	MET210
F	GLU211
F	CYS213
F	GLU217
F	LEU267
F	HOH515
F	HOH532
F	HOH536
F	HOH563

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL F 399

Chain	Residue
F	GLU264
F	LEU302
F	TYR303
F	PHE328

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGDVHlVeerssgle..........RVIK

Chain	Residue	Details
A	LEU141-LYS164

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHkDLKpeNILF

Chain	Residue	Details
A	VAL256-PHE268

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU264
A	ASP260

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS262
D	ASP260

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	LYS262
E	ASP260

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	LYS262
F	ASP260

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS262
A	THR300
A	ASP260

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS262
B	THR300
B	ASP260

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS262
C	THR300
C	ASP260

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	LYS262
F	THR300
F	ASP260

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS262
A	ASN265
A	ASP260

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS262
B	ASN265
B	ASP260

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS262
C	ASN265
C	ASP260

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	GLU264
B	ASP260

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS262
D	ASN265
D	ASP260

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	LYS262
E	ASN265
E	ASP260

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	LYS262
F	ASN265
F	ASP260

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	GLU264
C	ASP260

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	GLU264
D	ASP260

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	GLU264
E	ASP260

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	GLU264
F	ASP260

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS262
A	ASP260

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS262
B	ASP260

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS262
C	ASP260

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PDB entries from 2024-07-10

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