3IR2

Crystal structure of the APOBEC3G catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	HOH17
A	HIS257
A	CYS288
A	CYS291

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1101

Chain	Residue
A	HOH48
A	HIS248
A	HIS250
B	CYS261

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 2

Chain	Residue
A	ARG213
A	GLY214
A	ARG215
B	ARG213
A	VAL212

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 385

Chain	Residue
A	GLU209
A	HIS367
A	HOH470
A	HOH480
A	HOH481
A	HOH482

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1001

Chain	Residue
B	HOH94
B	HIS257
B	CYS288
B	CYS291

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1101

Chain	Residue
A	HOH46
A	CYS261
B	HIS248
B	HIS250

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1

Chain	Residue
A	ARG213
B	ARG213
B	ARG215
B	TRP285

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 385

Chain	Residue
B	HOH144
B	ILE337
B	SER372
B	HOH411

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM

Chain	Residue	Details
A	HIS257-MET295

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"CMP/dCMP-type deaminase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	254
Details	Region: {"description":"Necessary for homooligomerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37419875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8H0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKA and CAMK2","evidences":[{"source":"PubMed","id":"21659520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---