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3IPY

X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004136molecular_functiondeoxyadenosine kinase activity
A0004137molecular_functiondeoxycytidine kinase activity
A0004138molecular_functiondeoxyguanosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006139biological_processnucleobase-containing compound metabolic process
A0006220biological_processpyrimidine nucleotide metabolic process
A0008144molecular_functionobsolete drug binding
A0009224biological_processCMP biosynthetic process
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019136molecular_functiondeoxynucleoside kinase activity
A0042803molecular_functionprotein homodimerization activity
A0043771molecular_functioncytidine kinase activity
A0106383biological_processdAMP salvage
A1901135biological_processcarbohydrate derivative metabolic process
A1901293biological_processnucleoside phosphate biosynthetic process
B0000166molecular_functionnucleotide binding
B0004136molecular_functiondeoxyadenosine kinase activity
B0004137molecular_functiondeoxycytidine kinase activity
B0004138molecular_functiondeoxyguanosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006139biological_processnucleobase-containing compound metabolic process
B0006220biological_processpyrimidine nucleotide metabolic process
B0008144molecular_functionobsolete drug binding
B0009224biological_processCMP biosynthetic process
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019136molecular_functiondeoxynucleoside kinase activity
B0042803molecular_functionprotein homodimerization activity
B0043771molecular_functioncytidine kinase activity
B0106383biological_processdAMP salvage
B1901135biological_processcarbohydrate derivative metabolic process
B1901293biological_processnucleoside phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MLT A 261
ChainResidue
AILE30
AHOH333
AALA31
ALYS34
ASER35
AGLU127
AARG128
AARG192
AARG194
AB87263

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE B87 A 263
ChainResidue
AILE30
AGLU53
ATYR86
APHE96
AGLN97
AARG104
AASP133
AGLU196
AILE200
APRO201
ATYR204
AMLT261
AB87264
AHOH335

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE B87 A 264
ChainResidue
AMET85
ATYR86
AGLU90
AASN140
ALEU141
ASER144
AGLU145
ACYS146
ATYR204
AB87263
AHOH284
AHOH337

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MLT B 262
ChainResidue
BILE30
BALA31
BLYS34
BARG128
BARG192
BARG194
BB87265
BHOH332

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR RESIDUE B87 B 265
ChainResidue
BILE30
BGLU53
BTYR86
BPHE96
BGLN97
BASP133
BPHE137
BGLU196
BILE200
BPRO201
BTYR204
BMLT262
BB87266
BHOH307
BHOH334
BHOH340

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE B87 B 266
ChainResidue
BMET85
BTYR86
BPHE96
BASN140
BLEU141
BSER144
BTYR204
BB87265
BHOH342
BHOH344

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255
ChainResidueDetails
AGLU127
BGLU127

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING:
ChainResidueDetails
AGLY28
BGLY28
BGLU53
BTYR86
BGLN97
BARG128
BASP133
BARG188
BGLU197
BGLU240
AGLU53
ATYR86
AGLN97
AARG128
AASP133
AARG188
AGLU197
AGLU240

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CK1 => ECO:0000305|PubMed:20637175
ChainResidueDetails
ATHR72
BTHR72

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20637175, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
BSER74

237423

PDB entries from 2025-06-11

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