3IPD

Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21

Replaces:  3HD9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
B	0005484	molecular_function	SNAP receptor activity
B	0006886	biological_process	intracellular protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
C	0000149	molecular_function	SNARE binding
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0017075	molecular_function	syntaxin-1 binding
E	0016020	cellular_component	membrane
E	0016192	biological_process	vesicle-mediated transport
F	0005484	molecular_function	SNAP receptor activity
F	0006886	biological_process	intracellular protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
G	0000149	molecular_function	SNARE binding
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0017075	molecular_function	syntaxin-1 binding

Functional Information from PROSITE/UniProt

site_id	PS00417
Number of Residues	20
Details	SYNAPTOBREVIN Synaptobrevin signature. NVDKVlERdqKLSeLdDRAD

Chain	Residue	Details
A	ASN49-ASP68

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site_id	PS00914
Number of Residues	40
Details	SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V

Chain	Residue	Details
B	ARG198-VAL237

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	ARG180
H	ARG180

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	GLN197
H	GLN197

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60879

Chain	Residue	Details
D	SER154
H	SER154

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:12459461

Chain	Residue	Details
D	SER187
H	SER187
B	LYS253
B	LYS256
F	LYS252
F	LYS253
F	LYS256

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X) => ECO:0000269|PubMed:28770820

Chain	Residue	Details
A	ARG66
E	ARG66

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site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX) => ECO:0000269|PubMed:1331807

Chain	Residue	Details
A	GLN76
E	GLN76

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site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG) => ECO:0000269|PubMed:7910017

Chain	Residue	Details
A	ALA81
E	ALA81

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