3IOG

Crystal structure of CphA N220G mutant with inhibitor 18

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	ASP120
A	CYS221
A	HIS263
A	SDF311

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	HOH330
A	HOH365
A	HOH28
A	THR181
A	LEU182
A	GLN183
A	GLU184

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 3

Chain	Residue
A	ASP179
A	ARG188
A	PHE190
A	HOH332
A	HOH423

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 308

Chain	Residue
A	HIS176
A	ASP177
A	GLY178
A	ASP179
A	HOH524

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 309

Chain	Residue
A	HOH64
A	HOH64
A	ARG140
A	ARG140
A	ARG143
A	ARG143
A	HOH362
A	HOH362

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 310

Chain	Residue
A	LYS97
A	ARG102
A	HOH214
A	LYS257
A	HOH324

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	ARG143
A	ARG143
A	LYS147
A	LYS147

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	LYS129
A	VAL170
A	LEU171
A	HOH270
A	LYS302
A	HOH410
A	HOH450
A	HOH495

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SDF A 311

Chain	Residue
A	ZN1
A	VAL67
A	TRP87
A	ASP120
A	HIS196
A	CYS221
A	LYS224
A	GLY232
A	ASN233
A	HIS263
A	HOH347
A	HOH419
A	HOH473

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. InTNyHTDraGGnaywksi.G

Chain	Residue	Details
A	ILE113-GLY133

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PdeqVLyGgCILK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19651913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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