3IL4
Structure of E. faecalis FabH in complex with acetyl CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ACO A 401 |
| Chain | Residue |
| A | THR34 |
| A | HIS250 |
| A | ALA252 |
| A | ARG255 |
| A | ASN280 |
| A | TRP38 |
| A | THR43 |
| A | ARG156 |
| A | SER157 |
| A | VAL160 |
| A | LEU161 |
| A | ARG221 |
| A | ILE223 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ACO B 401 |
| Chain | Residue |
| B | ASP33 |
| B | THR34 |
| B | TRP38 |
| B | ILE39 |
| B | THR43 |
| B | CYS117 |
| B | ARG156 |
| B | ARG221 |
| B | ILE223 |
| B | PHE224 |
| B | HIS250 |
| B | ALA252 |
| B | ARG255 |
| B | ASN280 |
| B | PHE312 |
| B | GLY313 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ACO C 401 |
| Chain | Residue |
| B | ASN296 |
| B | GLY297 |
| C | THR34 |
| C | TRP38 |
| C | ARG42 |
| C | THR43 |
| C | CYS117 |
| C | ARG156 |
| C | SER157 |
| C | VAL160 |
| C | LEU161 |
| C | GLY220 |
| C | ARG221 |
| C | ILE223 |
| C | PHE224 |
| C | HIS250 |
| C | ALA252 |
| C | SER253 |
| C | ARG255 |
| C | ILE256 |
| C | ASN280 |
| C | PHE312 |
| C | GLY313 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ACO D 401 |
| Chain | Residue |
| D | THR34 |
| D | TRP38 |
| D | ARG42 |
| D | THR43 |
| D | ARG156 |
| D | VAL160 |
| D | LEU161 |
| D | ARG221 |
| D | ILE223 |
| D | PHE224 |
| D | HIS250 |
| D | ALA252 |
| D | ILE256 |
| D | ASN280 |
| D | PHE312 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Region: {"description":"ACP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| A | ASN280 | |
| A | CYS117 | |
| A | HIS250 | |
| A | PHE162 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| B | ASN280 | |
| B | CYS117 | |
| B | HIS250 | |
| B | PHE162 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| C | ASN280 | |
| C | CYS117 | |
| C | HIS250 | |
| C | PHE162 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| D | ASN280 | |
| D | CYS117 | |
| D | HIS250 | |
| D | PHE162 |
