3IHJ
Human alanine aminotransferase 2 in complex with PLP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004021 | molecular_function | L-alanine:2-oxoglutarate aminotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042851 | biological_process | L-alanine metabolic process |
| A | 0042853 | biological_process | L-alanine catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PLP A 1 |
| Chain | Residue |
| A | HOH3 |
| A | TYR302 |
| A | SER338 |
| A | LYS341 |
| A | ARG350 |
| A | GLY186 |
| A | ALA187 |
| A | SER188 |
| A | TYR216 |
| A | ILE267 |
| A | ASN271 |
| A | ASP299 |
| A | VAL301 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 524 |
| Chain | Residue |
| A | SER52 |
| A | MET53 |
| A | ASN54 |
| A | ASN94 |
| A | TYR440 |
| A | ARG494 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 2 |
| Chain | Residue |
| A | ARG312 |
| A | HIS314 |
| A | LYS318 |
| A | LYS469 |
| A | LYS521 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2009","submissionDatabase":"PDB data bank","title":"Human glutamate pyruvate transaminase 2.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3IHJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2009","submissionDatabase":"PDB data bank","title":"Human glutamate pyruvate transaminase 2.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3IHJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BGT5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ay4 |
| Chain | Residue | Details |
| A | TYR216 | |
| A | LYS341 | |
| A | ASP299 |
