3IFA
Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0005986 | biological_process | sucrose biosynthetic process |
A | 0006000 | biological_process | fructose metabolic process |
A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
A | 0006094 | biological_process | gluconeogenesis |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016791 | molecular_function | phosphatase activity |
A | 0030018 | cellular_component | Z disc |
A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
A | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
A | 0042578 | molecular_function | phosphoric ester hydrolase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070161 | cellular_component | anchoring junction |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0005986 | biological_process | sucrose biosynthetic process |
B | 0006000 | biological_process | fructose metabolic process |
B | 0006002 | biological_process | fructose 6-phosphate metabolic process |
B | 0006094 | biological_process | gluconeogenesis |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016791 | molecular_function | phosphatase activity |
B | 0030018 | cellular_component | Z disc |
B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
B | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
B | 0042578 | molecular_function | phosphoric ester hydrolase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070161 | cellular_component | anchoring junction |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0005986 | biological_process | sucrose biosynthetic process |
C | 0006000 | biological_process | fructose metabolic process |
C | 0006002 | biological_process | fructose 6-phosphate metabolic process |
C | 0006094 | biological_process | gluconeogenesis |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016791 | molecular_function | phosphatase activity |
C | 0030018 | cellular_component | Z disc |
C | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
C | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
C | 0042578 | molecular_function | phosphoric ester hydrolase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0070062 | cellular_component | extracellular exosome |
C | 0070161 | cellular_component | anchoring junction |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005886 | cellular_component | plasma membrane |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0005986 | biological_process | sucrose biosynthetic process |
D | 0006000 | biological_process | fructose metabolic process |
D | 0006002 | biological_process | fructose 6-phosphate metabolic process |
D | 0006094 | biological_process | gluconeogenesis |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016791 | molecular_function | phosphatase activity |
D | 0030018 | cellular_component | Z disc |
D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
D | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
D | 0042578 | molecular_function | phosphoric ester hydrolase activity |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070161 | cellular_component | anchoring junction |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE AMP A 339 |
Chain | Residue |
A | VAL17 |
A | LYS112 |
A | TYR113 |
A | ARG140 |
A | THR177 |
A | HOH363 |
A | HOH390 |
A | HOH415 |
A | HOH515 |
A | HOH538 |
A | LYS20 |
A | GLY21 |
A | ALA24 |
A | THR27 |
A | GLY28 |
A | GLU29 |
A | LEU30 |
A | THR31 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE AMP B 339 |
Chain | Residue |
B | VAL17 |
B | LYS20 |
B | GLY21 |
B | ALA24 |
B | GLY26 |
B | THR27 |
B | GLY28 |
B | GLU29 |
B | LEU30 |
B | THR31 |
B | LYS112 |
B | TYR113 |
B | THR177 |
B | HOH344 |
B | HOH345 |
B | HOH417 |
B | HOH423 |
B | HOH424 |
B | HOH447 |
site_id | AC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE AMP C 339 |
Chain | Residue |
C | VAL17 |
C | LYS20 |
C | GLY21 |
C | ALA24 |
C | GLY26 |
C | THR27 |
C | GLY28 |
C | GLU29 |
C | LEU30 |
C | THR31 |
C | LYS112 |
C | TYR113 |
C | VAL160 |
C | THR177 |
C | HOH373 |
C | HOH405 |
C | HOH462 |
C | HOH568 |
C | HOH569 |
C | HOH587 |
site_id | AC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE AMP D 339 |
Chain | Residue |
D | VAL17 |
D | LYS20 |
D | GLY21 |
D | ALA24 |
D | GLY26 |
D | THR27 |
D | GLY28 |
D | GLU29 |
D | LEU30 |
D | THR31 |
D | LYS112 |
D | TYR113 |
D | ARG140 |
D | THR177 |
D | HOH357 |
D | HOH358 |
D | HOH375 |
D | HOH521 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 340 |
Chain | Residue |
A | ASN212 |
A | TYR215 |
A | ARG243 |
A | TYR244 |
A | TYR264 |
A | LYS274 |
A | HOH397 |
A | HOH549 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 341 |
Chain | Residue |
A | LYS274 |
A | ARG276 |
A | ARG313 |
A | HOH452 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 342 |
Chain | Residue |
A | GLY122 |
A | SER123 |
A | SER124 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 343 |
Chain | Residue |
A | LYS207 |
A | SER237 |
A | ALA238 |
A | HOH431 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 340 |
Chain | Residue |
B | LYS274 |
B | HOH362 |
B | ASN212 |
B | TYR215 |
B | ARG243 |
B | TYR244 |
B | TYR264 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 341 |
Chain | Residue |
B | GLY122 |
B | SER123 |
B | SER124 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 342 |
Chain | Residue |
B | LYS274 |
B | ARG276 |
B | ARG313 |
B | HOH405 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 340 |
Chain | Residue |
C | ASP121 |
C | GLY122 |
C | SER123 |
C | SER124 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 341 |
Chain | Residue |
C | ASN212 |
C | TYR215 |
C | ARG243 |
C | TYR244 |
C | TYR264 |
C | HOH571 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 342 |
Chain | Residue |
C | LYS274 |
C | ARG276 |
C | ARG313 |
site_id | BC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 D 340 |
Chain | Residue |
D | ASN212 |
D | TYR215 |
D | ARG243 |
D | TYR244 |
D | TYR264 |
D | LYS274 |
D | HOH364 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 341 |
Chain | Residue |
D | LYS274 |
D | ARG276 |
D | ARG313 |
D | HOH371 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 342 |
Chain | Residue |
D | ASP121 |
D | GLY122 |
D | SER123 |
D | SER124 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 344 |
Chain | Residue |
A | ASN99 |
A | LYS100 |
A | ASP101 |
A | HOH641 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 345 |
Chain | Residue |
A | LYS217 |
A | TYR218 |
A | LYS269 |
A | HOH430 |
A | HOH445 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 346 |
Chain | Residue |
A | LYS203 |
A | LYS204 |
A | LYS205 |
A | HOH401 |
site_id | CC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 343 |
Chain | Residue |
B | ASN99 |
B | LYS100 |
B | ASP101 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 343 |
Chain | Residue |
C | ASN99 |
C | LYS100 |
C | ASP101 |
C | HOH431 |
site_id | CC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL D 343 |
Chain | Residue |
D | GLU98 |
D | ASN99 |
D | LYS100 |
D | ASP101 |
D | GLU146 |
Functional Information from PROSITE/UniProt
site_id | PS00124 |
Number of Residues | 13 |
Details | FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA |
Chain | Residue | Details |
A | GLY273-ALA285 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22120740 |
Chain | Residue | Details |
C | VAL17 | |
C | THR27 | |
C | LYS112 | |
C | ARG140 | |
D | VAL17 | |
D | THR27 | |
D | LYS112 | |
D | ARG140 | |
A | VAL17 | |
A | THR27 | |
A | LYS112 | |
A | ARG140 | |
B | VAL17 | |
B | THR27 | |
B | LYS112 | |
B | ARG140 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP68 | |
A | ASP121 | |
A | ASN212 | |
A | TYR244 | |
A | TYR264 | |
A | LYS274 | |
A | GLU280 | |
B | ASP68 | |
B | GLU97 | |
B | ASP118 | |
B | LEU120 | |
B | ASP121 | |
B | ASN212 | |
B | TYR244 | |
B | TYR264 | |
B | LYS274 | |
B | GLU280 | |
C | ASP68 | |
C | GLU97 | |
C | ASP118 | |
C | LEU120 | |
C | ASP121 | |
C | ASN212 | |
C | TYR244 | |
C | TYR264 | |
C | LYS274 | |
C | GLU280 | |
D | ASP68 | |
D | GLU97 | |
D | ASP118 | |
D | LEU120 | |
D | ASP121 | |
D | ASN212 | |
D | TYR244 | |
D | TYR264 | |
D | LYS274 | |
D | GLU280 | |
A | GLU97 | |
A | ASP118 | |
A | LEU120 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Important for the conversion from active R-state to inactive T-state in the presence of AMP |
Chain | Residue | Details |
A | GLN32 | |
B | GLN32 | |
C | GLN32 | |
D | GLN32 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1 |
Chain | Residue | Details |
A | TYR215 | |
A | TYR218 | |
B | TYR215 | |
B | TYR218 | |
C | TYR215 | |
C | TYR218 | |
D | TYR215 | |
D | TYR218 |